Featured Research

from universities, journals, and other organizations

More Findings On Gene Involved In Childhood Asthma

Date:
September 16, 2008
Source:
Children's Hospital of Philadelphia
Summary:
Asthma researchers have found that a gene variant known to raise the risk of childhood asthma in European children plays a similar role in white American children, but not in African-American children. The new findings showed the gene was involved in both milder and more severe forms of asthma.

Asthma researchers have found that a gene variant known to raise the risk of childhood asthma in European children plays a similar role in white American children, but not in African American children.

The most common chronic illness among children in the developed world, asthma is a complex disease in which a variety of genes are thought to interact with each other and with environmental influences to produce its effects. As in many other genetic diseases, researchers expect that better knowledge of gene associations will pave the way for new treatments and to customizing treatments to each patient's genetic profile.

Researchers from The Children's Hospital of Philadelphia found that variants in the ORMDL3 gene were associated with childhood-onset asthma among U.S. patients of European ancestry. In 2007 a study team based in Europe had identified the ORMDL3 gene, located on chromosome 17, as contributing to childhood asthma among British and German children.

The current study, from The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, appeared as a brief online report Aug. 29 in the Journal of Allergy and Clinical Immunology.

"We replicated the European findings among American children, and showed that the gene plays a role in asthma of any severity level," said study leader and pediatric pulmonologist Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at Children's Hospital. "The previous group had detected the association of ORMDL3 with asthma by examining families having two or three members with severe disease."

Furthermore, said Hakonarson, "Through the testing of additional markers, our data suggest that other genes outside the region occupied by ORMDL3 might have important roles in raising susceptibility to asthma." His group plans further studies to further refine this and other regions.

Drawing on patients from the Children's Hospital network, the study team analyzed DNA from 807 white children with asthma, compared to 2,583 white children without the disease. Another cohort consisted of African American children, of whom 1,456 had asthma and 1,973 were healthy controls. The researchers used highly automated gene-scanning equipment at Children's Hospital's Center for Applied Genomics, the largest pediatric genotyping program in the world.

"Because asthma is a very heterogeneous disease, the genes involved in childhood-onset asthma may be very different from those involved in asthma that first appears in adults," said Hakonarson. "Furthermore, the biological mechanisms by which genetic variants contribute to asthma are not well understood. However, we will continue our investigations, to shed light on how we might use genetic knowledge to develop more effective treatments for this common disease. These treatments will be a form of personalized medicine, better tailored to the genetic makeup of the individual patient."

An Institute Development Award from The Children's Hospital of Philadelphia supported this research. Hakonarson's co-authors, all from Children's Hospital, included Patrick M.A. Sleiman, Ph.D., Julian Allen, M.D., Jonathan Spergel, M.D., Ph.D., Robert Grundmeier, M.D., Ph.D., Michael M. Grunstein, M.D., Ph.D., and Mark Magnusson, M.D. Hans Bisgaard, M.D., from the University of Copenhagen, Denmark, also collaborated.


Story Source:

The above story is based on materials provided by Children's Hospital of Philadelphia. Note: Materials may be edited for content and length.


Cite This Page:

Children's Hospital of Philadelphia. "More Findings On Gene Involved In Childhood Asthma." ScienceDaily. ScienceDaily, 16 September 2008. <www.sciencedaily.com/releases/2008/09/080915122721.htm>.
Children's Hospital of Philadelphia. (2008, September 16). More Findings On Gene Involved In Childhood Asthma. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/09/080915122721.htm
Children's Hospital of Philadelphia. "More Findings On Gene Involved In Childhood Asthma." ScienceDaily. www.sciencedaily.com/releases/2008/09/080915122721.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins