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Genetic Research Using Human Samples Requires New Types Of Informed Consent

Date:
September 18, 2008
Source:
Public Library of Science
Summary:
Genetic studies involving the long term storage and study of human samples hold great promise for medical research -- but they also pose new threats to individuals such as uninsurability, unemployability, and discrimination, say a team of researchers in this week's PLoS Medicine.
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Genetic studies involving the long term storage and study of human samples hold great promise for medical research—but they also pose new threats to individuals such as uninsurability, unemployability, and discrimination, say a team of researchers in this week's PLoS Medicine.

Matthias Wjst (Institute of Genetic Medicine, Bozen, Italy) and colleagues argue that the traditional informed consent process—in which the researcher counsels potential study participants about the risks and benefits of taking part in a study—may no longer be appropriate when dealing with long-term studies using biological materials.

"In current practice," say the authors, "the only moment when a person is really able to make a choice about participating in clinical research is when they sign the informed consent form."

But they argue that there is a major problem with asking participants to sign this form as a "once-and-for-all decision"—a biological sample collected from a study participant for one study today might feasibly be of use in a future study several years down the line. New genetic information that is obtained from these later studies, if released, could lead to "uninsurability, unemployability, discrimination, and the breakdown of family relationships by unintentionally demonstrating missing or unknown relatedness."

"Informed consent should be seen as an ongoing process between researcher and participant, and not just as a once-and- for-all decision," say Wjst and colleagues.

They argue that any research following the initial storage of samples needs to be explained to the participants so that they can give their feedback. The authors suggest that such communications could involve both conventional channels—face-to face meetings, group meetings, and letters—as well as newer electronic communications—such as e-mail alerts, online chat rooms, and blogs.


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The above post is reprinted from materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mascalzoni D, Hicks A, Pramstaller P, Wjst M. Informed consent in the genomics era. PLoS Med, 2008; 5(9): e192 DOI: 10.1371/journal.pmed.0050192

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Public Library of Science. "Genetic Research Using Human Samples Requires New Types Of Informed Consent." ScienceDaily. ScienceDaily, 18 September 2008. <www.sciencedaily.com/releases/2008/09/080916101150.htm>.
Public Library of Science. (2008, September 18). Genetic Research Using Human Samples Requires New Types Of Informed Consent. ScienceDaily. Retrieved July 28, 2015 from www.sciencedaily.com/releases/2008/09/080916101150.htm
Public Library of Science. "Genetic Research Using Human Samples Requires New Types Of Informed Consent." ScienceDaily. www.sciencedaily.com/releases/2008/09/080916101150.htm (accessed July 28, 2015).

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