Featured Research

from universities, journals, and other organizations

Cost-effectiveness Of HIV Monitoring Strategy In Countries With Limited Resources Examined

Date:
September 22, 2008
Source:
JAMA and Archives Journals
Summary:
In a computer-based model evaluating the benefits and costs of three types of HIV disease monitoring strategies, early initiation of antiretroviral therapy and monitoring using the CD4 count, a measure of immune system function, instead of based on symptoms appear to provide health benefits in low- and middle-income countries, according to a new report.

In a computer-based model evaluating the benefits and costs of three types of HIV disease monitoring strategies, early initiation of antiretroviral therapy and monitoring using the CD4 count, a measure of immune system function, instead of based on symptoms appear to provide health benefits in low- and middle-income countries, according to a new report.

Related Articles


"Two-thirds of the world's HIV-infected population resides in Africa, and most of the world's new infections occur in low- and middle-income countries," the authors write as background information in the article. Although progress has been made in increasing access to treatment, only 20 percent of adults who need highly active antiretroviral therapy (HAART) receive it. Among those who do, treatment is often managed without regular checks of CD4 counts (lower counts indicate less immune system function) or viral loads; this lack of monitoring may decrease HAART's effectiveness. "Therefore, key questions in the management of HIV infection in resource-constrained settings are whether and how to monitor persons infected with HIV and when to initiate HAART."

Eran Bendavid, M.D., of Stanford University, Calif., and colleagues developed a computer model to compare three types of HIV monitoring strategies for starting, switching and stopping HAART: those based on symptoms, those based on CD4 counts and those that combine CD4 counts with viral load. "We used clinical and cost data from southern Africa and performed a cost-effectiveness analysis," the authors write. "All assumptions were tested in sensitivity analyses."

Compared with approaches based on symptoms, monitoring CD4 counts every six months and beginning treatment when CD4 counts reached 200 cells per microliter was associated with an additional 6.5 months of life expectancy and a reduction in lifetime medical costs of $464 per person. CD4-based strategies in which treatment was initiated at the higher threshold of 350 cells per microliter provided an additional 5.3 months of life expectancy at a cost-effectiveness of $107 per year gained compared with the 200-per-microliter threshold. The increased life expectancy with CD4 count monitoring was associated with a large decrease in opportunistic infections—314 fewer during the course of 1,000 patients' lifetimes.

"Monitoring viral load with CD4 was more expensive than monitoring CD4 counts alone, added two months of life and had an incremental cost-effectiveness ratio of $5,414 per life-year gained relative to monitoring of CD4 counts," the authors write. In sensitivity analyses, monitoring by CD4 count became more cost-effective as the average costs of inpatient care in a given country increased, because the monitoring was associated with fewer hospitalizations for opportunistic infections. The cost-effectiveness of monitoring viral load depended on the cost of the test in that area as well as the rates of virologic failure, which occurs when treatment fails to reduce the levels of virus in a patient's blood.

"Our analysis shows that, where HAART is available, CD4 count monitoring with earlier treatment initiation provides a substantial increase in life expectancy, which in some settings may be achievable while reducing total expenditures for HIV infection," the authors write. "As the number of persons receiving HAART increases, the potential health benefit and cost savings from use of CD4 monitoring will also increase."

This study was supported in part by grants from the Agency for Healthcare Research and Quality and from the National Institute on Drug Abuse, and the Department of Veterans Affairs.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bendavid et al. Cost-effectiveness of HIV Monitoring Strategies in Resource-Limited Settings: A Southern African Analysis. Archives of Internal Medicine, 2008; 168 (17): 1910 DOI: 10.1001/archinternmed.2008.1

Cite This Page:

JAMA and Archives Journals. "Cost-effectiveness Of HIV Monitoring Strategy In Countries With Limited Resources Examined." ScienceDaily. ScienceDaily, 22 September 2008. <www.sciencedaily.com/releases/2008/09/080922174628.htm>.
JAMA and Archives Journals. (2008, September 22). Cost-effectiveness Of HIV Monitoring Strategy In Countries With Limited Resources Examined. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2008/09/080922174628.htm
JAMA and Archives Journals. "Cost-effectiveness Of HIV Monitoring Strategy In Countries With Limited Resources Examined." ScienceDaily. www.sciencedaily.com/releases/2008/09/080922174628.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins