Featured Research

from universities, journals, and other organizations

When/if To Start Hormones For Prostate Cancer Patients Whose PSA Rises After Radiation

Date:
September 23, 2008
Source:
Fox Chase Cancer Center
Summary:
A new study suggests men with early stage prostate cancer treated with radiation therapy should begin hormone therapy immediately if their PSA level rises quickly and doubles within six months at any time after treatment. The study also supports foregoing hormones if the PSA doesn't rise as quickly. Both findings suggest a change in the practice of prescribing hormones is warranted.

A new Fox Chase Cancer Center study suggests men with early stage prostate cancer treated with radiation therapy should begin hormone therapy immediately if their PSA level rises quickly and doubles within six months at any time after treatment.

The study also supports foregoing hormones if the PSA doesn't rise as quickly. Both findings suggest a change in the practice of prescribing hormones is warranted.

After treatment for prostate cancer, many men will experience fluctuations or bounces in their PSA level, but for some the PSA continues to rise and doesn't return to its lowest point immediately after treatment. Knowing if or when to recommend hormone treatment (androgen deprivation therapy) depends on how much and how quickly the PSA rises – called the PSA doubling time. Hormone therapy has been shown to kill cancer cells and improve survival, but it carries a risk of side effects.

"We've been using PSA doubling time to help guide our decision about when to begin hormone therapy, but this study gives us new and critical information that suggests we should start therapy sooner than previously thought for some patients and delay treatment for others," explains Eric Horwitz, M.D., acting chairman and clinical director of the radiation oncology department at Fox Chase, who led the study. "While hormone therapy can have side effects such as hot flashes, decreased libido and osteoporosis, it can help prevent the cancer from spreading to the bones, causing pain and leading to an earlier death from the disease."

Previous studies indicated an increased likelihood that the cancer had spread if the PSA doubling time occurred within 12 months, and thus a potential benefit from receiving hormone therapy. But recently, a newly validated formula, known as the Phoenix definition, used by physicians demonstrates a more accurate way of determining biochemical failure, a term used to describe a significant rise in PSA. Using the new formula, the Fox Chase team was able to determine when earlier action needs to be taken.

"What we now know is that when the PSA rises and doubles within 6 months, versus 12 months, we need to act," explains Horwitz. "Our study suggests that these are the men who will benefit most from hormone therapy." Horwitz's research was presented today at the 50th annual meeting of the American Society for Therapeutic Radiology and Oncology.

Also, Horwitz says the study helps identify who is less likely to benefit from hormone therapy which may indicate a necessary change in current practice.

"Men whose PSA rises, but does so over a longer period of time may not benefit from hormones.

"These results further refine the role of PSA doubling time in predicting which patients may benefit from hormone therapy and which patients may be observed expectantly and spared the toxicity of the hormones," Horwitz concludes.

In addition to Horwitz, other authors include Karen Ruth, Robert G. Uzzo, Mark Buyyounouski, Yu-Ning Wong, David Y.T. Chen, of Fox Chase Cancer Center and Alan Pollack, of University of Miami/Sylvester Comprehensive Cancer Center. The authors report no disclosures.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "When/if To Start Hormones For Prostate Cancer Patients Whose PSA Rises After Radiation." ScienceDaily. ScienceDaily, 23 September 2008. <www.sciencedaily.com/releases/2008/09/080923121947.htm>.
Fox Chase Cancer Center. (2008, September 23). When/if To Start Hormones For Prostate Cancer Patients Whose PSA Rises After Radiation. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2008/09/080923121947.htm
Fox Chase Cancer Center. "When/if To Start Hormones For Prostate Cancer Patients Whose PSA Rises After Radiation." ScienceDaily. www.sciencedaily.com/releases/2008/09/080923121947.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins