Featured Research

from universities, journals, and other organizations

Hormone Therapy May Be Safe For Postmenopausal BRCA Mutation Carriers

Date:
September 29, 2008
Source:
Journal of the National Cancer Institute
Summary:
The use of hormone therapy was associated with a reduced risk of breast cancer in postmenopausal women who carry BRCA mutations, according to a case-control study.

The use of hormone therapy was associated with a reduced risk of breast cancer in postmenopausal women who carry BRCA mutations, according to a case-control study.

Related Articles


Women who carry a mutation in the BRCA1 gene may opt to have their ovaries removed to lower their risk of developing breast cancer. The surgery, however, induces menopause, and thus some women opt to take hormone therapy to reduce its symptoms. The impact of hormone therapy on the risk of breast cancer in these women is not known.

To find out, Steven Narod, M.D., of the University of Toronto and colleagues compared the use of hormone therapy in 236 breast cancer patients and 236 matched control subjects. All of the study participants carried a mutation in BRCA1.

Narod and colleagues report that 68 (29%) of the control subjects had used hormone therapy at some time, as had 47 (20%) of the women in the breast cancer group. The use of hormone therapy was associated with a 42% relative reduction in the risk of developing breast cancer. The researchers did not find a difference in risk reduction associated with estrogen-only or estrogen-progesterone therapies, however the reduction did not reach statistical significance in the estrogen-progesterone subgroup. The researchers did not detect a difference in risk reduction between women who had undergone natural, age-related menopause and those who had undergone surgically induced menopause.

"The magnitude of the association appeared to be as great, or even greater, for women after surgical menopause than it was for women after natural menopause. This information should be reassuring to women who wish to undergo preventive oophorectomy before menopause, but it needs to be confirmed in subsequent studies," the authors write.

In an accompanying editorial, Rowan Chlebowski, M.D., Ph.D., of the Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, and Ross Prentice, Ph.D., of the Fred Hutchinson Cancer Research Center in Seattle caution that observational studies have misled the field previously. Whereas earlier observational trials suggested that hormone therapy was not associated with an increased risk of breast cancer recurrence, randomized trials found a statistically significant increase in risk with menopausal hormone therapy use in breast cancer survivors.

"The results presented by [Narod and colleagues] regarding hormone therapy use in postmenopausal BRCA1 mutation carriers provide some evidence for safety but are insufficient to reliably inform routine clinical practice," the editorialists write. "As a result, continued caution in prescribing hormone therapy to women with BRCA1 mutations who are at high risk for breast cancers remains prudent."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eisen A, Lubinski J, Gronwald J, Moller P, Lynch HT, Klijn J, Kim-Sing C, et al. Hormone Therapy and the Risk of Breast Cancer in BRCA1 Mutation Carriers. J Natl Cancer Inst, Sept 23, 2008;100:1361

Cite This Page:

Journal of the National Cancer Institute. "Hormone Therapy May Be Safe For Postmenopausal BRCA Mutation Carriers." ScienceDaily. ScienceDaily, 29 September 2008. <www.sciencedaily.com/releases/2008/09/080923164544.htm>.
Journal of the National Cancer Institute. (2008, September 29). Hormone Therapy May Be Safe For Postmenopausal BRCA Mutation Carriers. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2008/09/080923164544.htm
Journal of the National Cancer Institute. "Hormone Therapy May Be Safe For Postmenopausal BRCA Mutation Carriers." ScienceDaily. www.sciencedaily.com/releases/2008/09/080923164544.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins