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What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?

Date:
September 24, 2008
Source:
World Journal of Gastroenterology
Summary:
Clostridium difficile associated diarrhea is the most common cause of health-care-associated diarrhea resulting in a spectrum of disease severity ranging from asymptomatic carriage to severe entero-colitis and death. A research group from Germany investigated risk factors for severe CDAD in hospitalized patients.

Clostridium difficile associated diarrhoea (CDAD) is the most common cause of healthcare-associated diarrhoea and results in a wide spectrum of disease severity ranging from asymptomatic carriage to life-threatening entero-colitis and death.

While many studies have investigated risk factors for infection with C. difficile and subsequent development of CDAD, little is known about risk factors associated with a severe course of CDAD in hospitalised patients.

A new research article addresses this question. The research team led by Prof. Franz Ludwig Dumoulin from Gemeinschaftskrankenhaus Bonn of German conducted a retrospective chart review on 124 hospitalised patients to identify risk factors for severe CDAD (associated with systemic signs of hypovolemia).

The study was conducted in community hospital treating approximately 19 000 in-patients per year. Major findings of the analysis are a 22% rate of severe CDAD which was significantly associated with a high 30-day mortality (33% vs 4%, P < 0.001) and a hospital stay exceeding 14 d (74% vs 52%, P = 0.048). In addition, co-morbidity assessed by the Charlson co-morbidity score (P < 0.05) and levels of serum C-reactive protein at the time of diagnosis (P < 0.001) were independent predictors of a severe course.

The findings have considerably impact on everyday clinical practice. Thus, hospitalized patients with a severe level of co-morbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention and treatment to counteract the threat of severe CDAD.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hardt et al. Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea: Importance of co-morbidity and serum C-reactive protein. World Journal of Gastroenterology, 2008; 14 (27): 4338 DOI: 10.3748/wjg.14.4338

Cite This Page:

World Journal of Gastroenterology. "What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?." ScienceDaily. ScienceDaily, 24 September 2008. <www.sciencedaily.com/releases/2008/09/080924111300.htm>.
World Journal of Gastroenterology. (2008, September 24). What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2008/09/080924111300.htm
World Journal of Gastroenterology. "What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?." ScienceDaily. www.sciencedaily.com/releases/2008/09/080924111300.htm (accessed September 16, 2014).

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