Featured Research

from universities, journals, and other organizations

What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?

Date:
September 24, 2008
Source:
World Journal of Gastroenterology
Summary:
Clostridium difficile associated diarrhea is the most common cause of health-care-associated diarrhea resulting in a spectrum of disease severity ranging from asymptomatic carriage to severe entero-colitis and death. A research group from Germany investigated risk factors for severe CDAD in hospitalized patients.

Clostridium difficile associated diarrhoea (CDAD) is the most common cause of healthcare-associated diarrhoea and results in a wide spectrum of disease severity ranging from asymptomatic carriage to life-threatening entero-colitis and death.

Related Articles


While many studies have investigated risk factors for infection with C. difficile and subsequent development of CDAD, little is known about risk factors associated with a severe course of CDAD in hospitalised patients.

A new research article addresses this question. The research team led by Prof. Franz Ludwig Dumoulin from Gemeinschaftskrankenhaus Bonn of German conducted a retrospective chart review on 124 hospitalised patients to identify risk factors for severe CDAD (associated with systemic signs of hypovolemia).

The study was conducted in community hospital treating approximately 19 000 in-patients per year. Major findings of the analysis are a 22% rate of severe CDAD which was significantly associated with a high 30-day mortality (33% vs 4%, P < 0.001) and a hospital stay exceeding 14 d (74% vs 52%, P = 0.048). In addition, co-morbidity assessed by the Charlson co-morbidity score (P < 0.05) and levels of serum C-reactive protein at the time of diagnosis (P < 0.001) were independent predictors of a severe course.

The findings have considerably impact on everyday clinical practice. Thus, hospitalized patients with a severe level of co-morbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention and treatment to counteract the threat of severe CDAD.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hardt et al. Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea: Importance of co-morbidity and serum C-reactive protein. World Journal of Gastroenterology, 2008; 14 (27): 4338 DOI: 10.3748/wjg.14.4338

Cite This Page:

World Journal of Gastroenterology. "What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?." ScienceDaily. ScienceDaily, 24 September 2008. <www.sciencedaily.com/releases/2008/09/080924111300.htm>.
World Journal of Gastroenterology. (2008, September 24). What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2008/09/080924111300.htm
World Journal of Gastroenterology. "What Is The Risk Factor For Severe Clostridium Difficile-associated Diarrhea?." ScienceDaily. www.sciencedaily.com/releases/2008/09/080924111300.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins