Featured Research

from universities, journals, and other organizations

Disease Diagnosis In Just 15 Minutes? Biosensor Technology Uses Antibodies To Detect Biomarkers Much Faster

Date:
October 1, 2008
Source:
University of Leeds
Summary:
Testing for diseases such as cancer and multiple sclerosis could soon be as simple as using a pregnancy testing kit. Scientists have developed a biosensor technology that uses antibodies to detect biomarkers -- molecules in the human body which are often a marker for disease -- much faster than current testing methods.

Scientists have developed a biosensor technology that uses antibodies to detect biomarkers much faster than current testing methods, paving the way for testing for diseases such as cancer and multiple sclerosis that could be as simple as using a pregnancy testing kit.
Credit: iStockphoto/Achim Prill

Testing for diseases such as cancer and multiple sclerosis could soon be as simple as using a pregnancy testing kit.

A team led by scientists at the University of Leeds has developed a biosensor technology that uses antibodies to detect biomarkers – molecules in the human body which are often a marker for disease – much faster than current testing methods.

The technology could be used in doctors' surgeries for more accurate referral to consultants, and in hospitals for rapid diagnosis. Tests have shown that the biosensors can detect a wide range of analytes (substances being measured), including biomarkers present in prostate and ovarian cancer, stroke, multiple sclerosis, heart disease and fungal infections. The team also believes that the biosensors are versatile enough to test for diseases such as tuberculosis and HIV.

The technology was developed through a European collaboration of researchers and commercial partners in a 2.7 million Euro project called ELISHA. It features new techniques for attaching antibodies to innovative surfaces, and novel electronic measurement methods that need no reagents or labels.

ELISHA was co-ordinated by Dr Paul Millner from the Faculty of Biological Sciences at the University of Leeds, and managed by colleague Dr Tim Gibson. Says Dr Millner: "We believe this to be the next generation diagnostic testing. We can now detect almost any analyte faster, cheaper and more easily than the current accepted testing methodology."

Currently blood and urine are tested for disease markers using a method called ELISA (Enzyme Linked Immunosorbant Assay). Developed in the 1970s, the process takes an average of two hours to complete, is costly and can only be performed by highly trained staff.

The Leeds team are confident their new technology – which provides results in 15 minutes or less - could be developed into a small device the size of a mobile phone into which different sensor chips could be inserted, depending on the disease being tested for.

"We've designed simple instrumentation to make the biosensors easy to use and understand," says Dr Millner. "They'll work in a format similar to the glucose biosensor testing kits that diabetics currently use."

Professor Séamus Higson, Dean of the Faculty of Medicine and Biosciences, Cranfield Health, and one of the partners within the ELISHA programme, says: "The speed of response this technology offers will be of great benefit to early diagnosis and treatment of many diseases, and will permit testing in de-localised environments such as GP's surgeries."

A spinout company – ELISHA Systems Ltd – has been set up by Dr Gibson, commercial partners Uniscan Instruments Ltd and Technology Translators Ltd to bring the technology to market.

Says Dr Gibson: "The analytes used in our research only scratch the surface of the potential applications. We've also shown that it can be used in environmental applications, for example to test for herbicides or pesticides in water and antibiotics in milk."

 


Story Source:

The above story is based on materials provided by University of Leeds. Note: Materials may be edited for content and length.


Cite This Page:

University of Leeds. "Disease Diagnosis In Just 15 Minutes? Biosensor Technology Uses Antibodies To Detect Biomarkers Much Faster." ScienceDaily. ScienceDaily, 1 October 2008. <www.sciencedaily.com/releases/2008/10/081001093231.htm>.
University of Leeds. (2008, October 1). Disease Diagnosis In Just 15 Minutes? Biosensor Technology Uses Antibodies To Detect Biomarkers Much Faster. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2008/10/081001093231.htm
University of Leeds. "Disease Diagnosis In Just 15 Minutes? Biosensor Technology Uses Antibodies To Detect Biomarkers Much Faster." ScienceDaily. www.sciencedaily.com/releases/2008/10/081001093231.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins