Featured Research

from universities, journals, and other organizations

Scientists Establish New Blood Test To Better Evaluate Prostate Cancer

Date:
October 1, 2008
Source:
The Institute of Cancer Research
Summary:
An international study led by researchers at The Institute of Cancer Research will pave the way for a test to be used to better tailor treatments and hopefully extend the survival of men with aggressive forms of metastatic prostate cancer.

An international study led by researchers at The Institute of Cancer Research will pave the way for a test to be used to better tailor treatments and hopefully extend the survival of men with aggressive forms of metastatic prostate cancer.

The study, to be published tomorrow for Cancer Clinical Research ( available online Oct 1,) has found that this analysis of Circulating Tumour Cells (CTC) can be utilised to study the prognosis of prostate cancer and is an independent indicator for overall survival of the disease.

Lead researcher Dr Johann de Bono at The Institute of Cancer Research and The Royal Marsden Hospital says:

“CTC testing, used in conjunction with the existing prostate specific antigen (PSA) test, may allow doctors to more accurately evaluate the effect of treatment on a patient’s tumour.”

“These studies are a very promising development, allowing cancer cells to be detected using a simple blood test and may eventually allow us to tailor cancer treatments to maximise the benefit for patients. Hopefully this will lead to improving the survival of patients with metastatic prostate cancer.”

The PSA test has been widely adopted as the benchmark test for prostate cancer in the UK, but it is not always possible to identify a clear relationship between a raised PSA level and the status of the disease.

Circulating tumour cells (CTCs) are cancer cells that have broken away from an existing tumour and have entered into the bloodstream. The presence of these cells in the blood provides valuable insights into disease progression.

This study has shown that the monitoring and detection of CTCs can provide valuable information on the patient’s prognosis. Further studies are taking place to evaluate if the CTC test may be used to allow doctors to make treatment decisions more quickly and more reliably for the benefit of patients.

The test has already been incorporated into several prostate cancer drug trials that are taking place at The Institute and The Royal Marsden.

The test has been cleared by the FDA in the United States to determine the prognosis of patients with metastatic breast, colorectal or prostate cancer.

The study was in partnership with the New-York based Memorial Sloan-Kettering Institute and involved 231 patients undergoing chemotherapy treatment. Sixty-five clinical centres in Europe and the U.S. took part in the study.

The patients underwent monthly CTC monitoring to measure the level of circulating tumour cells in the blood. A count of more than 5 CTC per 7.5 ml of blood was seen as an indicator towards an “unfavourable” prognosis whereas a count of less than 5 CTC per 7.5ml was considered “favourable”. This was compared with the progression of the metastatic prostate cancer tumours.

The Cellsearch™ Circulating Tumor Cell (CTC) test is available for commercial use in the United States by Veridex, LLC, a Johnson & Johnson company.

This study was funded by Immunicon Corporation, Huntingdon, PA.


Story Source:

The above story is based on materials provided by The Institute of Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

The Institute of Cancer Research. "Scientists Establish New Blood Test To Better Evaluate Prostate Cancer." ScienceDaily. ScienceDaily, 1 October 2008. <www.sciencedaily.com/releases/2008/10/081001094340.htm>.
The Institute of Cancer Research. (2008, October 1). Scientists Establish New Blood Test To Better Evaluate Prostate Cancer. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2008/10/081001094340.htm
The Institute of Cancer Research. "Scientists Establish New Blood Test To Better Evaluate Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/10/081001094340.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins