Featured Research

from universities, journals, and other organizations

Nanoparticles Used To Deliver Treatment For Brain, Spinal Cord Injuries

Date:
October 2, 2008
Source:
Purdue University
Summary:
Researchers have developed a method of using nanoparticles to deliver treatments to injured brain and spinal cord cells. Scientists coated silica nanoparticles with a polymer to target and repair injured guinea pig spinal cords. They then used the coated nanoparticles to deliver both the polymer and hydralazine to cells with secondary damage from a naturally produced toxin.

Purdue University researchers have developed a method of using nanoparticles to deliver treatments to injured brain and spinal cord cells.

Related Articles


A team led by Richard Borgens of the School of Veterinary Medicine's Center for Paralysis Research and Welden School of Biomedical Engineering coated silica nanoparticles with a polymer to target and repair injured guinea pig spinal cords. That research is being published in the October edition of the journal Small.

The team then used the coated nanoparticles to deliver both the polymer and hydralazine to cells with secondary damage from a naturally produced toxin. That research was published in August by the journal Nanomedicine.

Borgens' group had previously shown benefits of the polymer polyethylene glycol, or PEG, to treat rats with brain injuries and dogs with spinal cord injuries. PEG specifically targets damaged cells and seals the injured area, reducing further damage. It also helps restore cell function, Borgens said.

In previous studies, PEG was mixed with saline and injected.

"Composition and concentration limited how much PEG we could get to the injury," he said.

"If you change the composition to make the PEG more potent, it produces ethylene glycol, the poison in antifreeze. If you change the concentration of PEG in another way, the solution becomes syrupy and difficult to inject."

So the team - which includes Youngnam Cho of the Center for Paralysis Research, Riyi Shi of the center and Weldon School, and Albena Ivanisevic of Weldon School and the Department of Chemistry - turned to silica nanoparticles.

"These particles are so tiny they can't be seen with a regular microscope. They are about the size of a large virus. So you can inject as many as you need. And they are safe inside bodies," Borgens said.

In the first study, the researchers coated the nanoparticles with PEG to treat guinea pig spinal cord injuries. The treated spinal cord cells showed improved physiological functioning.

In the second study, the researchers added both PEG and hydralazine, an antihypertension drug, to mesoporous silica nanoparticles. These nanoparticles have pores that can hold the drug, which is later delivered to the damaged cells. The hydralazine was added to fight off secondary damage to cells that occurs after the initial injury.

"When cells are injured, they produce natural toxins," Borgens said. "Acrolein is the most poisonous of these toxins. It's an industrial hazard for which hydralazine is an antidote."

Borgens and his team introduced acrolein into cells and then treated the cells with different combinations of hydralazine and/or PEG delivered by the mesoporous silica nanoparticles.

They found that the treatment restored disrupted cell function caused by acrolein.

The team concluded that the use of nanoparticles to deliver both PEG and hydralazine increased the effectiveness of earlier PEG-only treatment by controlling and concentrating release of the drug and the polymer, producing a dual treatment and prolonging the treatment's duration.

The goal of Borgens' research is to improve the quality of life of those who have suffered head or spinal cord injuries.

"All ambulances should have PEG on board," he said. "It can probably save thousands of people from more severe head and spinal damage."

Financial support for the studies came from the state of Indiana and an endowment from Mari Hulman George.

The researchers now are testing the PEG/hydralazine treatment on rats with brain injuries. By the end of the year, they hope to test the treatment on naturally injured paraplegic dogs.


Story Source:

The above story is based on materials provided by Purdue University. Note: Materials may be edited for content and length.


Cite This Page:

Purdue University. "Nanoparticles Used To Deliver Treatment For Brain, Spinal Cord Injuries." ScienceDaily. ScienceDaily, 2 October 2008. <www.sciencedaily.com/releases/2008/10/081001145120.htm>.
Purdue University. (2008, October 2). Nanoparticles Used To Deliver Treatment For Brain, Spinal Cord Injuries. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2008/10/081001145120.htm
Purdue University. "Nanoparticles Used To Deliver Treatment For Brain, Spinal Cord Injuries." ScienceDaily. www.sciencedaily.com/releases/2008/10/081001145120.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins