Featured Research

from universities, journals, and other organizations

Endoscopic Therapy May Offer An Alternative To Surgery In Patients With Esophageal Cancer

Date:
October 13, 2008
Source:
American College of Gastroenterology
Summary:
New research has evaluated the long-term efficacy of endoscopic mucosal resection, or EMR, in the treatment of patients with early stage esophageal cancer or Barrett's esophagus. Two separate studies suggest EMR is an effective treatment alternative to surgery and generally yields positive long-term results.

Endoscopic therapy is emerging as an alternative to surgery in patients with esophageal cancer given the low likelihood of spread to the lymph nodes. New research presented at the American College of Gastroenterology's 73rd Annual Scientific Meeting in Orlando evaluated the long-term efficacy of endoscopic mucosal resection, or EMR, in the treatment of patients with early stage esophageal cancer or Barrett's esophagus.

Related Articles


Two separate studies suggest EMR is an effective treatment alternative to surgery and generally yields positive long-term results.

Dr. Ganapathy Prasad and colleagues from the Mayo Clinic in Rochester, MN reviewed the medical records of 135 esophageal cancer patients treated endoscopically (without surgery) at their clinic between 1995 and 2007. Minimally invasive techniques, such as EMR and photodynamic therapy were used to treat these patients.

After a 3.5-year follow-up, researchers found that endoscopic therapy was successful in 90 percent of esophageal cancer patients. Fourteen percent of patients had recurrent cancers, which appeared after a mean of 16 months. All of these recurrent cancers were early cancers and were treated endoscopically. Patients with recurrent cancers had longer Barrett's esophagus segments and needed more treatments to achieve remission. Overall, 83 percent of patients treated for esophageal cancer were alive at the 5-year mark.

According to lead investigator Dr. Prasad, "The results of this study show that early cancers of the esophagus can be treated endoscopically without surgery. Recurrences are uncommon and can be treated endoscopically as well, if patients are followed carefully."

CBE-EMR Effective Approach for the Management of Barrett's Esophagus

New research on an endoscopic procedure known as Complete Barrett's Esophagus Endoscopic Mucosal Resection (CBE-EMR) reveals this approach may hold promise as a minimally invasive technique offering an effective treatment alternative to surgical removal of the esophagus for Barrett's esophagus.

In a retrospective study of a prospectively collected database conducted at the University of Chicago, Dr. Jennifer Chennat and her colleagues, under the direction of Dr. Irving Waxman, examined medical records of 48 patients who underwent CBE-EMR for the treatment of Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma from August 2003 to May 2008.

Patients received careful endoscopic examination using high definition endoscopy with narrow band imaging. Endoscopic ultrasound was used prior to CBE-EMR to detect any invasive esophageal cancer or abnormal lymph nodes.

Patients continued to take proton pump inhibitors twice daily to decrease gastric acid production and reflux into the esophagus. After the CBE-EMR was completed, patients underwent an endoscopy every six months with biopsies taken every 1 cm throughout the entire length of the prior resected BE area, and also from 1 cm above the prior resection margin.

"Mucosal biopsies provide smaller pieces of tissue, while endoscopic mucosal resection provides more comprehensive tissue analysis. You're seeing not just the trees, but also the entire forest," explained Dr. Chennat.


Story Source:

The above story is based on materials provided by American College of Gastroenterology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Gastroenterology. "Endoscopic Therapy May Offer An Alternative To Surgery In Patients With Esophageal Cancer." ScienceDaily. ScienceDaily, 13 October 2008. <www.sciencedaily.com/releases/2008/10/081006092650.htm>.
American College of Gastroenterology. (2008, October 13). Endoscopic Therapy May Offer An Alternative To Surgery In Patients With Esophageal Cancer. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2008/10/081006092650.htm
American College of Gastroenterology. "Endoscopic Therapy May Offer An Alternative To Surgery In Patients With Esophageal Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/10/081006092650.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins