Featured Research

from universities, journals, and other organizations

Novel Lung Cancer Vaccine Trial Launched At Moores UCSD Cancer Center

Date:
October 7, 2008
Source:
University of California - San Diego
Summary:
Oncologists are hoping to stave off the relentless march of advanced lung cancer by treating patients with a novel kind of cancer vaccine. While many vaccines attempt to pump up the immune system to fight off a cancer, the new vaccine, Lucanix, is genetically engineered to also trick the cancer into turning off its immune system-suppressing activities.

Oncologists at the Moores Cancer Center at the University of California, San Diego (UCSD) in La Jolla are hoping to stave off the relentless march of advanced lung cancer by treating patients with a novel kind of cancer vaccine. While many vaccines attempt to pump up the immune system to fight off a cancer, the new vaccine, Lucanix, is genetically engineered to also trick the cancer into turning off its immune system-suppressing activities.

Related Articles


The first patients have begun enrolling in a new clinical trial at the Moores UCSD Cancer Center testing the effectiveness of the vaccine. The trial will involve 700 patients at some 90 centers worldwide.

Current treatments for advanced lung cancer have limited effectiveness and new therapies are needed, said Lyudmila Bazhenova, M.D., director of the Lung Cancer Unit at the Moores UCSD Cancer Center and assistant clinical professor of medicine at UC San Diego School of Medicine.

"The future treatments for advanced lung cancer may involve combinations of chemotherapy and targeted agents, and possibly even biologicals such as this," she said.

Roughly 430 patients die of lung cancer every day in the United States, according to Bazhenova, making it the nation's number one killer, despite being the second most common cancer. "While breast cancer mortality has declined about 15 percent, there hasn't been much improvement in mortality in lung cancer in the past several decades," she said. According to the American Cancer Society, an estimated 215,000 new cases of lung cancer will be diagnosed, and 162,000 individuals will die from the disease this year in the United States.

The vaccine, developed by NovaRx, a biopharmaceutical company based in San Diego, consists of lung cancer cells that have been genetically altered to shut down the cancer's ability to depress the immune system. In addition, the cells are also modified to enable the immune system to see them better.

Bazhenova explained that earlier tests of the vaccine's effectiveness produced encouraging results. The current trial is for patients with stage four non-small cell lung cancer who have completed four to six cycles of platinum-based chemotherapy. Those patients who have had a response to the treatment, meaning either tumor shrinkage or stable disease, may be eligible. The trial is a double-blind, placebo-controlled study, where neither patients nor doctors know who is getting the vaccine and who may be receiving a placebo. Patients receive injections once a month for 18 months, after which they receive two quarterly injections and are treated until disease progression. The trial's main goal is to determine if the vaccine can improve patient survival compared to taking placebo.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University of California - San Diego. "Novel Lung Cancer Vaccine Trial Launched At Moores UCSD Cancer Center." ScienceDaily. ScienceDaily, 7 October 2008. <www.sciencedaily.com/releases/2008/10/081007155058.htm>.
University of California - San Diego. (2008, October 7). Novel Lung Cancer Vaccine Trial Launched At Moores UCSD Cancer Center. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2008/10/081007155058.htm
University of California - San Diego. "Novel Lung Cancer Vaccine Trial Launched At Moores UCSD Cancer Center." ScienceDaily. www.sciencedaily.com/releases/2008/10/081007155058.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins