Featured Research

from universities, journals, and other organizations

Common Variant Increase Risk Of Most Common Form Of Skin Cancer By 170%

Date:
October 14, 2008
Source:
deCode Genetics
Summary:
Scientists report the discovery of common versions of two single-letter variations in the human genome (SNPs) that confer risk of basal cell carcinoma (BCC), the most common cancer among people of European ancestry. Unlike the four sets of SNPs previously found by deCODE to confer risk of BCC and cutaneous melanoma, those reported today are not linked to fair pigmentation traits that also make certain people prone to freckling and sunburn.

Scientists at deCODE genetics have report the discovery of common versions of two single-letter variations in the human genome (SNPs) that confer risk of basal cell carcinoma (BCC), the most common cancer among people of European ancestry. Unlike the four sets of SNPs previously found by deCODE to confer risk of BCC and cutaneous melanoma, those currently reported are not linked to fair pigmentation traits that also make certain people prone to freckling and sunburn.

These SNPs, both located on chromosome 1, may therefore provide new insight into an underlying biological mechanism causing BCC, independent of the impact of exposure to ultraviolet (UV) radiation in sunlight.

Approximately 2% of people of European descent carry two copies of the risk versions of both SNPs, and are at a 170% greater risk of BCC than those who do not carry the risk variants. The paper, entitled ‘Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigrmentation traits,’ appears in the online edition of Nature Genetics.

“With this discovery we continue to build our portfolio of novel risk factors for common skin cancers, diseases that cause significant morbidity and that are on the rise in the industrialized world. Once again we have used our capabilities in human genetics to gain a new understanding of the root causes of a major disease, that appear to act independently of known environmental risk factors. These two SNPs can also be used to enable individuals to better understand their own susceptibility to BCC and thus to take measures to lower their environmental and overall risk, and we are pleased to have added them already to our deCODEme™ service,” said Kari Stefansson, CEO of deCODE and senior author of the study.

The SNPs were discovered through the analysis of more than 300,000 SNPs across the genomes of more than 900 Icelanders with BCC and more than 33,000 control subjects. The SNPs most strongly correlated with BCC were then validated through the analysis of additional Icelandic and Eastern European cohorts of approximately 4,000 cases and controls. The deCODE team then analyzed data from more than 42,000 individuals from Iceland, Sweden and Spain to demonstrate that these novel variants conferring risk of BCC do not correlate with either fair pigmentation or with risk of cutaneous melanoma.

The SNPs currently reported thus appear to confer risk independently of that of variants in or near the MC1R, ASIP, TYR and TYRP1 genes that deCODE has reported in earlier studies.


Story Source:

The above story is based on materials provided by deCode Genetics. Note: Materials may be edited for content and length.


Cite This Page:

deCode Genetics. "Common Variant Increase Risk Of Most Common Form Of Skin Cancer By 170%." ScienceDaily. ScienceDaily, 14 October 2008. <www.sciencedaily.com/releases/2008/10/081013141438.htm>.
deCode Genetics. (2008, October 14). Common Variant Increase Risk Of Most Common Form Of Skin Cancer By 170%. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/10/081013141438.htm
deCode Genetics. "Common Variant Increase Risk Of Most Common Form Of Skin Cancer By 170%." ScienceDaily. www.sciencedaily.com/releases/2008/10/081013141438.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins