Featured Research

from universities, journals, and other organizations

HORIZONS AMI Will Help Set Guidelines For Drug And Stent Therapy

Date:
October 15, 2008
Source:
Cardiovascular Research Foundation
Summary:
The HORIZONS AMI clinical trial measuring the safety and efficacy of the use of the medication bivalirudin compared to standard drug therapy -- heparin and glycoprotein IIb/IIIa inhibitors -- in heart attack patients who receive angioplasty, found that after 1 year, use of bivalirudin resulted in significantly lower rates of all-cause death, death from cardiac causes, and major bleeding.

The HORIZONS AMI clinical trial measuring the safety and efficacy of the use of the medication bivalirudin compared to standard drug therapy – heparin and glycoprotein IIb/IIIa inhibitors -- in heart attack patients who receive angioplasty, found that after 1 year, use of bivalirudin resulted in significantly lower rates of all-cause death, death from cardiac causes, and major bleeding.

Related Articles


Late-breaking data presented at the 20th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF), show that the use of the anticoagulant bivalirudin reduced net adverse clinical events (NACE) by 16% compared to the standard treatment. In addition, use of bivalirudin significantly reduced the major bleeding that occurs after angioplasty by 39% one year after the angioplasty was performed.

The use of bivalirudin also resulted in a significant 31% reduction in the 1-year rate of all cause mortality and a 43% reduction in the 1-year rate of cardiac mortality, with non-significant differences in the rate of repeat heart attack, stent thrombosis, stroke and target vessel revascularization (TVR) at 1 year.

"These 1-year results, which are even more impressive than the 30-day data reported at TCT one year ago, ensure that HORIZONS AMI will have a dramatic and lasting impact on the way that heart attack patients are treated during percutaneous coronary intervention," said Gregg W. Stone, M.D., CRF Chairman, Professor of Medicine and the Director of Research and Education at the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center, and Principal Investigator of the HORIZONS-AMI trial. "The use of bivalirudin rather than heparin plus glycoprotein IIb/IIIa inhibitors reduced the rate of death and cardiac death by 1.4% and 1.7% respectively, which potentially could result in thousands of lives saved per year on a global basis."

"HORIZONS has demonstrated that the prevention of hemorrhagic complications after primary percutaneous coronary intervention in heart attack patients results in improved early and late survival," said Roxana Mehran, M.D., Joint Chief Scientific Officer of the Clinical Trials Center at CRF and Director of Outcomes Research, Data Coordination and Analysis at the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center. She and her team conducted the study under an Investigational Device Exemption (IDE) from the Food and Drug Administration.

"Optimal drug selection and technique to minimize bleeding are essential to enhance outcomes for patients undergoing interventional therapies," Dr. Mehran said.

While previous studies of drug-eluting stents have often focused on their use in patients with stable or unstable chest pain, this is the largest study to focus on the appropriate use of anticoagulation medications and drug-eluting stents in patients experiencing the most dangerous form of heart attack (ST-elevation myocardial infarction).

Sponsored by the Cardiovascular Research Foundation, with research grant support from Boston Scientific Corporation and The Medicines Company, the HORIZONS AMI (Harmonizing Outcomes with RevascularIZatiON and Stents in Acute Myocardial Infarction) trial enrolled over 3,600 patients presenting with a heart attack to hospitals in 11 countries. More than 120 national and international interventional cardiology centers participated in the trial. Patients undergoing angioplasty were randomly assigned to receive either the prior standard anticoagulant regimen of unfractionated heparin plus a glycoprotein IIb/IIIa inhibitor or bivalirudin alone. The patients are to be followed for five years.



Story Source:

The above story is based on materials provided by Cardiovascular Research Foundation. Note: Materials may be edited for content and length.


Cite This Page:

Cardiovascular Research Foundation. "HORIZONS AMI Will Help Set Guidelines For Drug And Stent Therapy." ScienceDaily. ScienceDaily, 15 October 2008. <www.sciencedaily.com/releases/2008/10/081015130634.htm>.
Cardiovascular Research Foundation. (2008, October 15). HORIZONS AMI Will Help Set Guidelines For Drug And Stent Therapy. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2008/10/081015130634.htm
Cardiovascular Research Foundation. "HORIZONS AMI Will Help Set Guidelines For Drug And Stent Therapy." ScienceDaily. www.sciencedaily.com/releases/2008/10/081015130634.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Newsy (Mar. 6, 2015) A new study found losing just half an hour of sleep could make you gain weight. Video provided by Newsy
Powered by NewsLook.com
Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins