Featured Research

from universities, journals, and other organizations

HIV-infected Patients Should Start HAART Sooner, Study Suggests

Date:
October 30, 2008
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
Under current treatment guidelines, highly active antiretroviral therapy should be considered for HIV-infected patients when their CD4+ T-cell counts fall below 350 cells per cubic millimeter (mm3). However, new epidemiological research suggests that patients with HIV may have less risk of dying if they begin HAART sooner.

Under current treatment guidelines, highly active antiretroviral therapy (HAART) should be considered for HIV-infected patients when their CD4+ T-cell counts fall below 350 cells per cubic millimeter (mm3). However, new epidemiological research suggests that patients with HIV may have less risk of dying if they begin HAART sooner.

HIV ravages CD4+ T-cells, one of the human immune system's primary weapons for fighting off infection. As virus levels increase in the blood, HIV-infected patients experience a decrease in CD4+ T-cells and declining health. HAART--a combination of at least three HIV medicines--is used to reduce virus levels.

Although current treatment guidelines recommend that patients begin HAART once their CD4+ T-cell counts fall below the 350 cells/mm3 threshold, the optimal time to begin therapy has been unclear because of insufficient clinical trial data. U.S. and Canadian researchers, working through the International Epidemiology Databases to Evaluate AIDS (IeDEA), set out to take steps towards establishing a clinical basis for initiating treatment.

IeDEA, a global network of clinics that serve HIV patients and collect data important to key HIV/AIDS research questions, was initiated by and is funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health (NIH). IeDEA is co-funded by the National Cancer Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

From 1996 to 2006, the research team examined 8,374 HIV-infected study participants with CD4+ T-cell counts of 351-500 cells/mm3 who had never taken antiretroviral treatment and were free of AIDS-related illnesses. Thirty percent (2,473) of the study participants began taking HAART, while the remaining 70 percent (5,901) of participants deferred treatment until their CD4+ T-cell counts fell below 350 cells/mm3. The researchers found a 71 percent higher risk of death for patients who deferred treatment rather than initiating HAART, suggesting that therapy should begin at an earlier stage of HIV disease than currently recommended. A randomized clinical trial will be necessary to confirm this finding and support changes to established treatment guidelines.

Mari M. Kitahata, M.D., of the University of Washington in Seattle, will present the findings on October 26, 2008, during the joint annual meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and the Infectious Diseases Society of America (IDSA) in Washington, D.C.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "HIV-infected Patients Should Start HAART Sooner, Study Suggests." ScienceDaily. ScienceDaily, 30 October 2008. <www.sciencedaily.com/releases/2008/10/081027101353.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2008, October 30). HIV-infected Patients Should Start HAART Sooner, Study Suggests. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2008/10/081027101353.htm
NIH/National Institute of Allergy and Infectious Diseases. "HIV-infected Patients Should Start HAART Sooner, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/10/081027101353.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins