Featured Research

from universities, journals, and other organizations

New Hormone Data Can Predict Menopause Within A Year

Date:
October 30, 2008
Source:
University of Michigan
Summary:
For many women, including the growing number who choose later-in-life pregnancy, predicting their biological clock's relation to the timing of their menopause and infertility is critically important.

For many women, including the growing number who choose later-in-life pregnancy, predicting their biological clock's relation to the timing of their menopause and infertility is critically important.

Now, investigators from the University of Michigan have provided new information about hormonal biomarkers that can address the beginning of the menopause transition.

"In the end, this information can change the way we do business," said MaryFran Sowers, professor in the U-M School of Public Health Department of Epidemiology. "The information provides a roadmap as to how fast women are progressing through the different elements of their reproductive life."

A research team headed by Sowers examined the naturally occurring changes in three different biomarkers over the reproductive life of more than 600 women: follicle-stimulating hormone (FSH), anti-Mullerian hormone (AMH) and inhibin B.

Researchers found that the biomarker AMH declined to a very low or non-measurable level five years prior to the final menstrual period. This decline pinpoints a critical juncture in which a woman probably has so few follicles (eggs) that her fertility becomes increasingly questionable, Sowers said. They found that the changes in AMH and inhibin B concentrations were predictive of the time to menopause.

The research team also measured and reported the rates of change in FSH and used the information to identify different reproductive stages. Based on a woman's age and the level of FSH in the blood, researchers were able to describe four different stages that occur for women from their late reproductive period to the time of their final menstrual period.

While clinicians have the ability to measure these hormones now, they haven't had the kind of information about AMH, inhibin B or FSH collected on a large group of women over time to know how to relate levels or changes in the levels to fertility or to a menopause endpoint.

"People really want information about how long do I have and when will I have my final menstrual period," Sowers said. "Now we are beginning to say, 'If you have a specific FSH level combined with your age, this is the likelihood that you are in this reproductive stage.'

"We finally have numbers from enough women evaluated over a long time period to describe the reproductive aging process. It begins to give women and clinicians an expanded way to look at menses and endocrine events in terms of reproductive progression."

Sowers said additional study results have been submitted to describe the amount of bone loss that occurs at the different FSH stages.Thus, if women and clinicians know where women are in the various reproductive stages, it will further their understanding of the likely health implications associated with each stage.

The research team also includes: Huiyong Zheng, Daniel McConnell, Bin Nan, Sioban Harlow, all of the U-M School of Public Health, and John F. Randolph Jr. of the U-M Department of Obstetrics and Gynecology.


Story Source:

The above story is based on materials provided by University of Michigan. Note: Materials may be edited for content and length.


Journal References:

  1. Sowers et al. Follicle Stimulating Hormone and Its Rate of Change in Defining Menopause Transition Stages. Journal of Clinical Endocrinology & Metabolism, 2008; 93 (10): 3958 DOI: 10.1210/jc.2008-0482
  2. Sowers et al. Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition. Journal of Clinical Endocrinology & Metabolism, 2008; 93 (9): 3478 DOI: 10.1210/jc.2008-0567

Cite This Page:

University of Michigan. "New Hormone Data Can Predict Menopause Within A Year." ScienceDaily. ScienceDaily, 30 October 2008. <www.sciencedaily.com/releases/2008/10/081027155901.htm>.
University of Michigan. (2008, October 30). New Hormone Data Can Predict Menopause Within A Year. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2008/10/081027155901.htm
University of Michigan. "New Hormone Data Can Predict Menopause Within A Year." ScienceDaily. www.sciencedaily.com/releases/2008/10/081027155901.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins