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Artificial Pancreas Could Revolutionize Treatment Of Type 1 Diabetes

Date:
October 30, 2008
Source:
University of Virginia
Summary:
Researchers across the globe are testing a computerized, subcutaneous system that could one day transform the way Type 1 diabetics manage their disease.

Researchers at the University of Virginia and sites across the globe are testing a computerized, subcutaneous system that could one day transform the way Type 1 diabetics manage their disease.

U.Va. investigators have completed the first of several international artificial pancreas clinical trials to test an individually-"prescribed" control algorithm, which regulates blood glucose levels in Type 1 diabetics. U.Va.is one of seven centers worldwide funded by the Juvenile Diabetes Research Foundation to perform the novel closed-loop computer simulation of the human metabolic system.

Since late June, researchers have successfully tested the new system on five patients at the U.Va. Health System. Three additional patients participated in a parallel study at the University of Padova, Italy.

"Our initial results are very encouraging," said Boris Kovatchev, associate professor of psychiatry and neurobehavioral sciences and of systems and information engineering, who is leading U.Va.'s research team. "The system entirely maintained the patients' blood glucose levels, and the algorithm achieved excellent overnight control without any incidence of hypoglycemia."

Kovatchev, internationally known for his expertise in applying advanced computational methods to diabetes research, was one of the scientists who developed the system's novel algorithm, which allows for personalized treatment for each patient. By linking patients' glucose monitors with their insulin pumps, the "smart" program automatically regulates the amount of insulin a patient needs.

Researchers were granted Food and Drug Administration approval, based solely on computer simulation experiments, to test the artificial pancreas in humans, without any prior animal trials. The action cut research development time from several years to six months.

"This artificial pancreas could one day greatly improve the current methods of self-treatment for Type 1 diabetes," Kovatchev said. "Instead of a patient having to measure his or her blood sugar with a glucose meter several times a day and self-administer insulin injections, this system would continuously regulate the patient's blood glucose, much like the way a non-diabetic's pancreas functions."

Complete results from the initial clinical trials at the U.Va.Health System, the University of Padova and the University of Montpellier, France, are expected by the end of 2008.


Story Source:

The above story is based on materials provided by University of Virginia. Note: Materials may be edited for content and length.


Cite This Page:

University of Virginia. "Artificial Pancreas Could Revolutionize Treatment Of Type 1 Diabetes." ScienceDaily. ScienceDaily, 30 October 2008. <www.sciencedaily.com/releases/2008/10/081029104717.htm>.
University of Virginia. (2008, October 30). Artificial Pancreas Could Revolutionize Treatment Of Type 1 Diabetes. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/10/081029104717.htm
University of Virginia. "Artificial Pancreas Could Revolutionize Treatment Of Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2008/10/081029104717.htm (accessed July 31, 2014).

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