Featured Research

from universities, journals, and other organizations

Seizures Following Parasitic Infection Associated With Brain Swelling

Date:
November 5, 2008
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
A new study provides strong evidence associating seizures with areas of brain tissue swelling in people infected by a parasitic tapeworm. The swellings, called perilesional edemas, form around dead, calcified cysts that result when larvae of Taenia solium tapeworms lodge in the brain. The illness caused by T. solium infection -- neurocysticercosis -- is the most common cause of adult-onset seizures and epilepsy in developing countries where the tapeworm is endemic.

A new study by National Institute of Allergy and Infectious Diseases (NIAID) scientist Theodore E. Nash, M.D., and colleagues provides strong evidence associating seizures with areas of brain tissue swelling in people infected by a parasitic tapeworm. The swellings, called perilesional edemas, form around dead, calcified cysts that result when larvae of Taenia solium tapeworms lodge in the brain.

Related Articles


The illness caused by T. solium infection—neurocysticercosis—is the most common cause of adult-onset seizures and epilepsy in developing countries where the tapeworm is endemic. Brain scans of individuals with this parasitic infection frequently show calcified cysts, but the clinical significance of perilesional edema around these calcifications and whether such edema is associated with seizures was not known.

The research was conducted in collaboration with Hector H. Garcia, M.D., in Lima, Peru. Dr. Nash, Dr. Garcia and their co-investigators studied 110 people with calcified cysts and a history of seizures. Between 1999 and 2006, 29 study participants had a seizure; of these, 24 were assessed by magnetic resonance imaging (MRI) within 5 days of the seizure. Perilesional edema was seen on MRI in 50 percent of cases (12 out of 24 patients)—a strong association between edema and seizure relapse. In a control group of patients with infection but without an incident seizure while enrolled in the study, only 9 percent (2 of 23 cases) had perilesional edema.

The scientists conclude that perilesional edema is common and is associated with episodic seizure activity in people who have calcified T. solium cysts. Since perilesional edema is not found in most common diseases causing seizures, its presence here suggests a different mechanism as a cause. Therefore, seizures due to T. solium infection may be preventable and treatable in novel ways including with agents that control this type of inflammation.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. TE Nash et al. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study. The Lancet Neurology, Online Nov. 4, 2008 DOI: 10.1016/S1474-4422(08)70244-8

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Seizures Following Parasitic Infection Associated With Brain Swelling." ScienceDaily. ScienceDaily, 5 November 2008. <www.sciencedaily.com/releases/2008/11/081103192415.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2008, November 5). Seizures Following Parasitic Infection Associated With Brain Swelling. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2008/11/081103192415.htm
NIH/National Institute of Allergy and Infectious Diseases. "Seizures Following Parasitic Infection Associated With Brain Swelling." ScienceDaily. www.sciencedaily.com/releases/2008/11/081103192415.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins