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Visualizing Asthma-causing Immune Cells At Work

Date:
November 17, 2008
Source:
Journal of Clinical Investigation
Summary:
Immune cells known as eosinophils have a central role in causing asthma. Researchers have now developed new approaches to noninvasively visualize in real-time eosinophil responses in the lungs and airways of mice with a disease that mimics asthma. It is hoped that these approaches might be exploited to improve our ability to diagnose asthma and assess the efficacy of treatments for the disease.
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Immune cells known as eosinophils have a central role in causing asthma. Now, a team of researchers at Massachusetts General Hospital, Boston, has developed approaches to noninvasively visualize in real-time eosinophil responses in the lungs and airways of mice with a disease that mimics asthma (experimental allergic airway inflammation); they hope that these approaches might be developed to help assess the efficacy of treatments (both old and new) for the disease.

The team, led by Mikael Pittet and Ralph Weissleder, visualized eosinophils at single-cell resolution using various noninvasive real-time molecular imaging technologies (specifically, near-infrared fluorescence fiber optic bronchoscopy, intravital microscopy, and fluorescence-mediated tomography) following injection of an optical sensor that targets proteins produced by eosinophils known as MMPs.

Using a combination of the sensitive optical sensor and fluorescence-mediated tomography, it was observed that dexamethasone (a drug used to treat severe asthma) decreased the number of eosinophils in the lungs of mice with allergic airway inflammation.

As some of the imaging techniques have the potential to be developed for the clinic, the authors suggest that in combination with an appropriate optical sensor they might improve our ability to diagnose asthma and assess treatment efficacy.


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The above post is reprinted from materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. Journal of Clinical Investigation, (in press)

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Journal of Clinical Investigation. "Visualizing Asthma-causing Immune Cells At Work." ScienceDaily. ScienceDaily, 17 November 2008. <www.sciencedaily.com/releases/2008/11/081106181411.htm>.
Journal of Clinical Investigation. (2008, November 17). Visualizing Asthma-causing Immune Cells At Work. ScienceDaily. Retrieved September 3, 2015 from www.sciencedaily.com/releases/2008/11/081106181411.htm
Journal of Clinical Investigation. "Visualizing Asthma-causing Immune Cells At Work." ScienceDaily. www.sciencedaily.com/releases/2008/11/081106181411.htm (accessed September 3, 2015).

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