Featured Research

from universities, journals, and other organizations

Chemotherapy Plus Targeted Therapies Shows Improved Survival In Advance-stage Lung Cancer Patients

Date:
November 26, 2008
Source:
American Society for Therapeutic Radiology and Oncology
Summary:
The combination of traditional chemotherapy agents with targeted therapies called monoclonal antibodies showed no safety concerns and improved survival in patients with advanced non-small cell lung cancer according to a study presented at the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago.

The combination of traditional chemotherapy agents with targeted therapies called monoclonal antibodies showed no safety concerns and improved survival in patients with advanced non-small cell lung cancer according to a study presented at the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago.

The combination of bevacizumab and chemotherapy has been shown to increase the survival of patients with incurable non-small cell lung cancer. Cetuximab has recently demonstrated improved survival when given in combination with platinum based chemotherapy.

Based on this information, researchers from M.D. Anderson Cancer Center in Houston, Fred Hutchison Cancer Research Center and the Cancer Research and Biostatistical Clinical Trials Consortium (CRAB), both in Seattle, the Cancer Center of Kansas in Wichita, Kan., Central Illinois CCOP in Springfield, Ill., the University of Kansas in Kansas City, Kan., and U.C. Davis Cancer Center in Sacramento, all part of the South West Oncology Group, sought to investigate the safety and efficacy of the combination of the four drugs in this multi-center phase II clinical trial.

This study, the first reported study of these two targeted therapies (bevacizumab and cetuximab) with chemotherapy (carboplatin and paclitaxel), combined the four drugs as first-line therapy in advanced lung cancer patients. The goal of this study was to assess the safety of the four drug regimen. No safety concerns were seen when compared with other treatments. Additionally, in the 104 patients evaluated between August 2006 and September 2007, improved survival was observed.

“The combination of multiple targeted therapies in addition to chemotherapy may be the future of treatment in lung cancer,” said Edward Kim, M.D., lead author of the study and an assistant professor in the department of thoracic/head and neck medical oncology at M.D. Anderson Cancer Center. “Blocking more key cancer pathways such as the epidermal growth factor receptor and vascular endothelial growth factor may lead to improved cancer control.”

The abstract, “S0563: SWOG Phase II Trial of Carboplatin (C), Paclitaxel (P), Cetuximab (CX) and Bevacizumab (B) Followed by Cetuximab and Bevacizumab in Advanced Non-small Cell Lung Cancer (NSCLC),” will be presented in Oral Abstract Session II on Thursday, November 13 at 10:15 a.m.


Story Source:

The above story is based on materials provided by American Society for Therapeutic Radiology and Oncology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Therapeutic Radiology and Oncology. "Chemotherapy Plus Targeted Therapies Shows Improved Survival In Advance-stage Lung Cancer Patients." ScienceDaily. ScienceDaily, 26 November 2008. <www.sciencedaily.com/releases/2008/11/081113091621.htm>.
American Society for Therapeutic Radiology and Oncology. (2008, November 26). Chemotherapy Plus Targeted Therapies Shows Improved Survival In Advance-stage Lung Cancer Patients. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/11/081113091621.htm
American Society for Therapeutic Radiology and Oncology. "Chemotherapy Plus Targeted Therapies Shows Improved Survival In Advance-stage Lung Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2008/11/081113091621.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins