Featured Research

from universities, journals, and other organizations

Cigarette Smoke Could Alter Shape Of Heart

Date:
November 14, 2008
Source:
University of Illinois at Chicago
Summary:
Prolonged exposure to cigarette smoke can increase levels of the stress hormone norepinephrine and enzymes in the heart that have the potential to reshape the left ventricle, according to new research.

Prolonged exposure to cigarette smoke can increase levels of the stress hormone norepinephrine and enzymes in the heart that have the potential to reshape the left ventricle, according to new research at the University of Illinois at Chicago.

In a study using rats as as animal model, five weeks exposure to cigarette smoke was associated with the activation of enzymes called mitogen-activated protein kinases that govern cell growth and survival in heart muscle. Activation of these enzymes may be a key event in cigarette smoke-induced heart injury, says Mariann Piano, professor of biobehavioral health science in the UIC College of Nursing and lead researcher of the study.

Heart disease probably develops as a result of complex interactions among many elements in cigarette smoke, she said.

"Cigarette smoke contains more than 4,000 different chemicals, one of which is nicotine," Piano said. "However, the effect of nicotine on the initiation and progression of cigarette smoke-mediated cardiovascular events remains controversial."

To date, small clinical trials of nicotine replacement therapies have not shown increased cardiovascular risk, even in patients with cardiovascular disease, Piano said. This suggested the need to study cigarette smoke as a whole.

In the new study, published in the November issue of the European Journal of Heart Failure, rats were exposed either to cigarette smoke or to normal room air. After five weeks, the animals were examined by echocardiography. Heart tissue was examined under the microscope and by Western blot analysis, used to detect specific proteins in tissue samples.

The results showed exposure to cigarette smoke was associated with significant changes in the shape of the left ventricle, the heart's main pumping chamber, and an increase in the levels of the activated forms of the enzymes in the heart muscle. Researchers also found increased levels of norepinephrine, a hormone released when a stressful event causes any of a host of physiological changes, in urine samples taken from the animals.

Piano said this is the first study to demonstrate that cigarette smoke-induced ventricular remodeling is linked to the activation of mitogen-activated protein kinases. She received the American Heart Association's 2008 Katharine A. Lembright Award for excellence in cardiovascular research at the association's annual meeting in New Orleans on Nov. 9.

The study was funded by the National Institutes of Health. Other authors were Lianzhi Gu, postdoctoral fellow in biobehavioral health science; and, from the UIC College of Medicine, Shamim Chowdhury, research scientist in physiology and biophysics, and Dr. David Geenen, research associate professor of physiology.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "Cigarette Smoke Could Alter Shape Of Heart." ScienceDaily. ScienceDaily, 14 November 2008. <www.sciencedaily.com/releases/2008/11/081113181432.htm>.
University of Illinois at Chicago. (2008, November 14). Cigarette Smoke Could Alter Shape Of Heart. ScienceDaily. Retrieved September 29, 2014 from www.sciencedaily.com/releases/2008/11/081113181432.htm
University of Illinois at Chicago. "Cigarette Smoke Could Alter Shape Of Heart." ScienceDaily. www.sciencedaily.com/releases/2008/11/081113181432.htm (accessed September 29, 2014).

Share This



More Health & Medicine News

Monday, September 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Why Is Big Tobacco Voluntarily Warning You About E-Cigs?

Why Is Big Tobacco Voluntarily Warning You About E-Cigs?

Newsy (Sep. 29, 2014) Big tobacco companies are voluntarily printing health warnings on their e-cigarette packages — a move some are calling part of a PR strategy. Video provided by Newsy
Powered by NewsLook.com
Why Pediatricians Endorse IUDs, Implants For Teens

Why Pediatricians Endorse IUDs, Implants For Teens

Newsy (Sep. 29, 2014) New recommendations from the American Academy of Pediatrics point to intrauterine devices and implants as good forms of birth control for teens. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins