Featured Research

from universities, journals, and other organizations

Helping The Embryo Implant: A New Role For One Type Of Immune Cell

Date:
November 28, 2008
Source:
Journal of Clinical Investigation
Summary:
One of the most critical stages in establishing a pregnancy is the implantation of the embryo in the wall of the uterus. Although the accumulation of immune cells known as DCs has been observed in the uterus after fertilization and prior to implantation, their function was not known.

One of the most critical stages in establishing a pregnancy is the implantation of the embryo in the wall of the uterus. Although the accumulation of immune cells known as DCs has been observed in the uterus after fertilization and prior to implantation, their function was not known.

However, Steffen Jung and colleagues, at The Weizmann Institute of Science, Israel, have now discovered that mouse uterine DCs are crucial for implantation and that they function to ensure that new blood vessels form in the wall of the uterus; they do not function by dampening immune responses to the embryo, as had been anticipated.

The authors used mice engineered such that they could be depleted of all their DCs (including those in the uterus) by administration of a toxin. Depletion of DCs in both normal mice and mice lacking the ability to mount an immune response resulted in a severe defect in implantation, indicating that uterine DCs had a role in implantation that was independent of their effects on the immune system.

Further analysis revealed that this role was to produce two factors (sFlt1 and TGF-beta-1) critical for coordinating blood vessel formation.

The importance of this work and the implications for understanding potential causes of human infertility where implantation is impaired as well as other pregnancy related complications (for example, preeclampsia) are discussed by both the authors and, in an accompanying commentary, Jeffrey Pollard, at Albert Einstein College of Medicine, New York.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Plaks et al. Uterine DCs are crucial for decidua formation during embryo implantation in mice. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI36682
  2. Pollard. Uterine DCs are essential for pregnancy. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37733

Cite This Page:

Journal of Clinical Investigation. "Helping The Embryo Implant: A New Role For One Type Of Immune Cell." ScienceDaily. ScienceDaily, 28 November 2008. <www.sciencedaily.com/releases/2008/11/081120172930.htm>.
Journal of Clinical Investigation. (2008, November 28). Helping The Embryo Implant: A New Role For One Type Of Immune Cell. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2008/11/081120172930.htm
Journal of Clinical Investigation. "Helping The Embryo Implant: A New Role For One Type Of Immune Cell." ScienceDaily. www.sciencedaily.com/releases/2008/11/081120172930.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins