Featured Research

from universities, journals, and other organizations

Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease

Date:
November 28, 2008
Source:
Journal of Clinical Investigation
Summary:
Females with cystic fibrosis have more severe disease than males with cystic fibrosis and have a shorter lifespan. Although many suggestions have been put forward to explain this sex-related difference, a concrete mechanism to explain it has remained elusive.

Females with cystic fibrosis have more severe disease than males with cystic fibrosis and have a shorter lifespan. Although many suggestions have been put forward to explain this sex-related difference, a concrete mechanism to explain it has remained elusive.

However, Robert Tarran and colleagues, at University of North Carolina, Chapel Hill, have now uncovered a molecular mechanism whereby the hormone estrogen has a negative impact on the clearance of mucus from the lungs; the buildup of mucus in the lung is a hallmark of cystic fibrosis and serves as a focus for severe infections.

As the estrogen antagonist tamoxifen blocked one aspect of the molecular mechanism in vitro, the authors suggest that antiestrogens might be beneficial in the treatment of cystic fibrosis.

In an accompanying commentary, Pamela Zeitlin, at Johns Hopkins School of Medicine, Baltimore, outlines the complexities of the molecular mechanism uncovered by Tarran and colleagues, and further discusses the clinical implications of the data.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Coakley et al. 17β-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI33893
  2. Zeitlin. Cystic fibrosis and estrogens: a perfect storm. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37778

Cite This Page:

Journal of Clinical Investigation. "Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease." ScienceDaily. ScienceDaily, 28 November 2008. <www.sciencedaily.com/releases/2008/11/081120173008.htm>.
Journal of Clinical Investigation. (2008, November 28). Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2008/11/081120173008.htm
Journal of Clinical Investigation. "Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease." ScienceDaily. www.sciencedaily.com/releases/2008/11/081120173008.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins