Featured Research

from universities, journals, and other organizations

Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease

Date:
November 28, 2008
Source:
Journal of Clinical Investigation
Summary:
Females with cystic fibrosis have more severe disease than males with cystic fibrosis and have a shorter lifespan. Although many suggestions have been put forward to explain this sex-related difference, a concrete mechanism to explain it has remained elusive.

Females with cystic fibrosis have more severe disease than males with cystic fibrosis and have a shorter lifespan. Although many suggestions have been put forward to explain this sex-related difference, a concrete mechanism to explain it has remained elusive.

However, Robert Tarran and colleagues, at University of North Carolina, Chapel Hill, have now uncovered a molecular mechanism whereby the hormone estrogen has a negative impact on the clearance of mucus from the lungs; the buildup of mucus in the lung is a hallmark of cystic fibrosis and serves as a focus for severe infections.

As the estrogen antagonist tamoxifen blocked one aspect of the molecular mechanism in vitro, the authors suggest that antiestrogens might be beneficial in the treatment of cystic fibrosis.

In an accompanying commentary, Pamela Zeitlin, at Johns Hopkins School of Medicine, Baltimore, outlines the complexities of the molecular mechanism uncovered by Tarran and colleagues, and further discusses the clinical implications of the data.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Coakley et al. 17β-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI33893
  2. Zeitlin. Cystic fibrosis and estrogens: a perfect storm. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37778

Cite This Page:

Journal of Clinical Investigation. "Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease." ScienceDaily. ScienceDaily, 28 November 2008. <www.sciencedaily.com/releases/2008/11/081120173008.htm>.
Journal of Clinical Investigation. (2008, November 28). Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2008/11/081120173008.htm
Journal of Clinical Investigation. "Hormones: The Reason Why Females With Cystic Fibrosis Have A Worse Outlook Than Males With The Disease." ScienceDaily. www.sciencedaily.com/releases/2008/11/081120173008.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins