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Pelvic Lymphadenectomy Does Not Improve Survival In Early-stage Endometrial Cancer

Date:
November 25, 2008
Source:
Journal of the National Cancer Institute
Summary:
Systematic use of pelvic lymphadenectomy does not improve disease-free or overall survival in women with early-stage endometrial cancer, according to a randomized trial.

Systematic use of pelvic lymphadenectomy (removal of the lymph nodes) does not improve disease-free or overall survival in women with early-stage endometrial cancer, according to a randomized trial.

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The first site of metastasis for endometrial cancer is often the pelvic lymph nodes. However, few prospective studies have examined whether systematic removal of the pelvic lymph nodes improves patient outcomes.

To find out, Pierluigi Benedetti Panici, M.D., of the La Sapienza University in Rome and colleagues conducted a randomized controlled trial in which women with stage I endometrial cancer were assigned to have a standard hysterectomy and ovary removal with or without lymphadenectomy.

With a median follow-up of four years, there was no difference in patient outcomes between the two arms. Thirty-four (12.9 percent) of the 264 patients in the lymphadenectomy group and 33 (13.2 percent) of the 250 patients in the control group had disease recurrence. The median time to disease recurrence was 14 months in the lymphadenectomy arm and 13 months in the control arm. Overall five-year survival estimates were 86 percent for the lymphadenectomy arm and 90 percent for the non-lymphadenectomy.

Surgical staging of the disease was improved with the systematic use of lymphadenectomy. A total of 13.3 percent of the women in the lymphadenectomy arm were found to have disease spread to pelvic lymph nodes, compared with 3.2 percent of the women in the control arm. The investigators found that although lymphadenectomy was not statistically significantly associated with improved survival, disease spread to the nodes was associated with poorer survival.

"Therefore, lymph¬adenectomy maintained its importance in determining a patient's prognosis and in tailoring adjuvant therapies," the authors conclude.

In an accompanying editorial, Christine Walsh, M.D., and Beth Karlan, M.D., of the Cedars-Sinai Medical Center in Los Angeles note that these new data are consistent with the one other randomized trial that examined the impact of lymphadenectomy on survival.

"These results bust the myth that is based on previous retrospective studies that lymphadenectomy, in and of itself, provides therapeutic ben¬efit and survival advantage in endometrial cancer," the editorialists write. "Yet, this trial continues to support the notion that lymphadenectomy can pro¬vide important prognostic information and can help guide adju¬vant treatment recommendations."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Benedetti Panici P, et al. Systematic Pelvic Lymphadenectomy vs No Lymphadenectomy in Early-Stage Endometrial Carcinoma: Randomized Clinical Trial. J Natl Cancer Inst, 2008; 100:1707-1716

Cite This Page:

Journal of the National Cancer Institute. "Pelvic Lymphadenectomy Does Not Improve Survival In Early-stage Endometrial Cancer." ScienceDaily. ScienceDaily, 25 November 2008. <www.sciencedaily.com/releases/2008/11/081125161421.htm>.
Journal of the National Cancer Institute. (2008, November 25). Pelvic Lymphadenectomy Does Not Improve Survival In Early-stage Endometrial Cancer. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2008/11/081125161421.htm
Journal of the National Cancer Institute. "Pelvic Lymphadenectomy Does Not Improve Survival In Early-stage Endometrial Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/11/081125161421.htm (accessed October 24, 2014).

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