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ShareDec. 17, 2008 — Researchers in Finland are reporting identification of the first potential "biomarker" that could be used in development of a sputum test for early detection of chronic obstructive pulmonary disease (COPD). That condition, which causes severe difficulty in breathing — most often in cigarette smokers — affects 12 million people in the United States.
Vuokko L. Kinnula and colleagues point out that no disease marker for COPD currently exists, despite extensive efforts by scientists to find one. Past research pointed to a prime candidate — surfactant protein A (SP-A), which has a major role in fighting infections and inflammation in the lung.
The scientists compared levels of a variety of proteins obtained from the lung tissues of healthy individuals, patients with COPD, and those with pulmonary fibrosis. They found that the lungs of COPD patients contained elevated levels of SP-A. The scientists also found elevated levels of SP-A in the sputum samples of COPD patients. "This suggests that SP-A might represent a helpful biomarker in the early detection of COPD and other related disorders," the article notes.
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The above story is reprinted from materials provided by American Chemical Society.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Ohlmeier et al. Proteomics of Human Lung Tissue Identifies Surfactant Protein A as a Marker of Chronic Obstructive Pulmonary Disease. Journal of Proteome Research, 2008; 7 (12): 5125 DOI: 10.1021/pr800423x
Note: If no author is given, the source is cited instead.
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