Featured Research

from universities, journals, and other organizations

Second-generation Chronic Myelogenous Leukemia Drugs Show Promise As Frontline Therapy

Date:
December 8, 2008
Source:
University of Texas M. D. Anderson Cancer Center
Summary:
Two drugs approved as fallback therapy for chronic myelogenous leukemia appear to outperform historical benchmarks of the frontline medication when used as a first treatment in separate clinical trials, researchers at The University of Texas M. D. Anderson Cancer Center reported at the 50th Annual Meeting of the American Hematological Society.

Two drugs approved as fallback therapy for chronic myelogenous leukemia (CML) appear to outperform historical benchmarks of the frontline medication when used as a first treatment in separate clinical trials, researchers at The University of Texas M. D. Anderson Cancer Center reported at the 50th Annual Meeting of the American Hematological Society.

Frontline therapy for CML remains imatinib, a Novartis drug known as Gleevec® and a success story in targeted cancer treatment that has increased the five-year survival rate for the disease from 50 percent to 90 percent of patients.

"We are seeing more patients achieve complete cytogenetic responses faster with either drug than we did during clinical trials with imatinib," said Jorge Cortes, M.D., professor in M. D. Anderson's Leukemia Department and leader of both studies. "These are early but encouraging results."

Complete cytogenetic response is the absence of the defective chromosome that causes the disease. Cortes and colleagues compare current clinical trial results to M. D. Anderson's extensive historical results from earlier trials of imatinib.

Researchers are comparing nilotinib, a Novartis drug known as Tasigna®, and dasatinib, a Bristol-Myers Squibb drug known as Sprycel®, to imatinib. Both are approved by the U.S. Food and Drug Administration for patients who can't tolerate imatinib or whose CML resists the drug.

The nilotinib trial has enrolled 49 patients with previously untreated early stage CML, and some with second stage disease. The 400mg twice daily dose led to complete cytogenetic response in nearly all patients as early as three months into the trial.

Overall, 44 of 46 (96 percent) evaluable patients have achieved a complete cytogenetic response at some point during the trial. At one year, 52 percent achieved a major molecular response, an even more stringent measure of disease remission.

The dasatinib trial has enrolled 50 patients with previously untreated early stage CML taking either 50 mg twice daily or 100 mg once a day. Overall, 44 of 45 patients (98 percent) have achieved complete cytogenetic response at some point during the trial. At one year, 34 percent have achieved major molecular response.

While both dasatinib and nilotinib have so far outperformed a 400mg daily dose of imatinib at all times, longer-term results are converging with those seen with an 800 mg daily dose of imatinib.

Both clinical trials continue to enroll patients. Side effects are being closely monitored and some patients in each trial had their doses reduced or treatment temporarily interrupted to deal with toxicities. "Side effects so far are manageable and comparable to those seen with imatinib," Cortes said.

Imatinib targets the aberrant Bcr-Abl protein, caused by a chromosomal abnormality called the Philadelphia Chromosome, which fuels an overabundance of white blood cells and immature stem cells called blasts that crowd out red blood cells and platelets. Nilotinib and dasatinib target a greater variety of genetic variations leading to CML and often work after imatinib has failed.

The clinical trials are funded by Novartis and Bristol-Myers Squibb who provide both study medicines for off-label use.

Co-authors with Cortes on the nilotinib trial are Susan O'Brien, M.D., Alessandra Ferrajoli, M.D., Gautam Borthakur, M.D., Guillermo Garcia-Manero, M.D., Marina Konopleva, M.D., Ph.D., and Hagop Kantarjian, M.D., all of M. D. Anderson's Department of Leukemia; Dan Jones, M.D., Ph.D., of M. D. Anderson's Department of Hematopathology, and Laurie A. Letvak, M.D., of Novartis.

Co-authors on the dasatinib trial are Farhad Ravandi, M.D., Charles Koller, M.D., Jianqin Shan, Ph.D., Ofelia Mesina, and O'Brien, Borthakur, Ferrajoli, and Kantarjian of the Department of Leukemia.

Cortes and Kantarjian receive research funding from both companies and Borthakur is on speakers bureaus for both companies.


Story Source:

The above story is based on materials provided by University of Texas M. D. Anderson Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Texas M. D. Anderson Cancer Center. "Second-generation Chronic Myelogenous Leukemia Drugs Show Promise As Frontline Therapy." ScienceDaily. ScienceDaily, 8 December 2008. <www.sciencedaily.com/releases/2008/12/081208180433.htm>.
University of Texas M. D. Anderson Cancer Center. (2008, December 8). Second-generation Chronic Myelogenous Leukemia Drugs Show Promise As Frontline Therapy. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2008/12/081208180433.htm
University of Texas M. D. Anderson Cancer Center. "Second-generation Chronic Myelogenous Leukemia Drugs Show Promise As Frontline Therapy." ScienceDaily. www.sciencedaily.com/releases/2008/12/081208180433.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins