Featured Research

from universities, journals, and other organizations

Drug-resistant Tuberculosis Rife In China

Date:
December 16, 2008
Source:
BMC Infectious Diseases
Summary:
Levels of drug-resistant tuberculosis in China are nearly twice the global average. Nationwide research published in the journal BMC Infectious Diseases has shown that almost 10 percent of Chinese TB cases are resistant to the most effective first-line drugs.

Levels of drug-resistant tuberculosis (TB) in China are nearly twice the global average. Nationwide research published in the journal BMC Infectious Diseases has shown that almost 10% of Chinese TB cases are resistant to the most effective first-line drugs.

Susan van den Hof, from the KNCV Tuberculosis Foundation in The Netherlands is one of the authors on a Chinese study into the prevalence of multi-drug resistant tuberculosis (MDR-TB). She said, "In order to obtain insight into the prevalence and distribution of resistance, China has joined the global project on anti-tuberculosis drug resistance surveillance, and investigated drug resistance in ten provinces between 1996 and 2004."

China has the second largest number of TB cases in the world, and is one of the countries with high levels of drug-resistant TB. According to the authors, "The prevalence of drug resistance varied greatly between the provinces, but on average was worryingly high, with a weighted mean for MDR-TB of 9.3% among all cases; 5.4% among new cases and 25.6% among previously treated cases. The global MDR-TB estimates are 4.8% for all cases, 3.1% for new cases and 19.3% for previously treated cases."

Treatment of MDR-TB requires use of costly, toxic and less effective second-line drugs and infected patients are less likely to survive treatment. In a well-functioning TB control program with low levels of defaulting from treatment, high resistance levels are expected among previously treated cases. This is consistent with the authors' observations in China. If a good TB control program is in place, the proportion of previously treated patients among all TB patients should also be low. In China the proportion of previously treated patients varied between the provinces but on average was about 20%, compared to a global average of 11%.

The authors said, "Many possible explanations for the development of drug resistance in China exist, and different explanations may prevail in different areas of this vast country. These include the inadequate use of anti-TB drugs in public hospitals, lack of supervision of treatment, poor drug-management and absence of infection control measures in hospitals. Also, availability of anti-TB drugs without a prescription in some areas of China in the past may have contributed to the development of drug resistance."

At this moment, programmatic treatment of MDR-TB cases with second-line drugs is being piloted in some areas of China. MDR-TB treatment will then be expanded within China to prevent further spread of MDR-TB and help to bring MDR-TB rates down.


Story Source:

The above story is based on materials provided by BMC Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. Guang Xue He, Yan Lin Zhao, Guang Lu Jiang, Yu Hong Liu, Hui Xia, Sheng Fen Wang, Li Xia Wang, Martien W Borgdorff, Marieke J van der Werf and Susan van den Hof. Prevalence of tuberculosis drug resistance in 10 provinces of China. BMC Infectious Diseases, (in press)

Cite This Page:

BMC Infectious Diseases. "Drug-resistant Tuberculosis Rife In China." ScienceDaily. ScienceDaily, 16 December 2008. <www.sciencedaily.com/releases/2008/12/081210205044.htm>.
BMC Infectious Diseases. (2008, December 16). Drug-resistant Tuberculosis Rife In China. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2008/12/081210205044.htm
BMC Infectious Diseases. "Drug-resistant Tuberculosis Rife In China." ScienceDaily. www.sciencedaily.com/releases/2008/12/081210205044.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins