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Your Genetic Make-up Influences The Levels Of Fats In Your Blood

Date:
December 23, 2008
Source:
Journal of Clinical Investigation
Summary:
A team of researchers has provided new insight into how genetic variation can cause different individuals to have distinct levels of a fat known as triglyceride in their blood.

A team of researchers, led by Helen Hobbs and Jonathan Cohen, at the University of Texas Southwestern Medical Center, Dallas, has provided new insight into how genetic variation can cause different individuals to have distinct levels of a fat known as triglyceride in their blood.

Results of their study appear online Dec. 15 in the Journal of Clinical Investigation.

The team focused on a family of genes known as ANGPTL genes and analyzed three family members (ANGPTL3, ANGPTL5, and ANGPT6L) in over 3,000 individuals. Several rare variations in the ANGPTL3 and ANGPTL5 genes were identified in individuals with low triglyceride levels in their blood and no other detectable defects in handling fats.

Previous studies have indicated a similar finding for ANGPTL4. Further analysis revealed that the ANGPTL3, ANGPTL4, and ANGPTL5 variants associated with low triglyceride levels in the blood generated proteins that had lost their normal function.

The team therefore conclude that variation in the ANGPTL3, ANGPTL4, and ANGPT6L genes contributes to the diversity of triglyceride levels in the blood of different individuals.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Romeo et al. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37118

Cite This Page:

Journal of Clinical Investigation. "Your Genetic Make-up Influences The Levels Of Fats In Your Blood." ScienceDaily. ScienceDaily, 23 December 2008. <www.sciencedaily.com/releases/2008/12/081217200648.htm>.
Journal of Clinical Investigation. (2008, December 23). Your Genetic Make-up Influences The Levels Of Fats In Your Blood. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2008/12/081217200648.htm
Journal of Clinical Investigation. "Your Genetic Make-up Influences The Levels Of Fats In Your Blood." ScienceDaily. www.sciencedaily.com/releases/2008/12/081217200648.htm (accessed April 24, 2014).

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