Featured Research

from universities, journals, and other organizations

Your Genetic Make-up Influences The Levels Of Fats In Your Blood

Date:
December 23, 2008
Source:
Journal of Clinical Investigation
Summary:
A team of researchers has provided new insight into how genetic variation can cause different individuals to have distinct levels of a fat known as triglyceride in their blood.

A team of researchers, led by Helen Hobbs and Jonathan Cohen, at the University of Texas Southwestern Medical Center, Dallas, has provided new insight into how genetic variation can cause different individuals to have distinct levels of a fat known as triglyceride in their blood.

Related Articles


Results of their study appear online Dec. 15 in the Journal of Clinical Investigation.

The team focused on a family of genes known as ANGPTL genes and analyzed three family members (ANGPTL3, ANGPTL5, and ANGPT6L) in over 3,000 individuals. Several rare variations in the ANGPTL3 and ANGPTL5 genes were identified in individuals with low triglyceride levels in their blood and no other detectable defects in handling fats.

Previous studies have indicated a similar finding for ANGPTL4. Further analysis revealed that the ANGPTL3, ANGPTL4, and ANGPTL5 variants associated with low triglyceride levels in the blood generated proteins that had lost their normal function.

The team therefore conclude that variation in the ANGPTL3, ANGPTL4, and ANGPT6L genes contributes to the diversity of triglyceride levels in the blood of different individuals.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Romeo et al. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37118

Cite This Page:

Journal of Clinical Investigation. "Your Genetic Make-up Influences The Levels Of Fats In Your Blood." ScienceDaily. ScienceDaily, 23 December 2008. <www.sciencedaily.com/releases/2008/12/081217200648.htm>.
Journal of Clinical Investigation. (2008, December 23). Your Genetic Make-up Influences The Levels Of Fats In Your Blood. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2008/12/081217200648.htm
Journal of Clinical Investigation. "Your Genetic Make-up Influences The Levels Of Fats In Your Blood." ScienceDaily. www.sciencedaily.com/releases/2008/12/081217200648.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins