Featured Research

from universities, journals, and other organizations

Your Genetic Make-up Influences The Levels Of Fats In Your Blood

Date:
December 23, 2008
Source:
Journal of Clinical Investigation
Summary:
A team of researchers has provided new insight into how genetic variation can cause different individuals to have distinct levels of a fat known as triglyceride in their blood.

A team of researchers, led by Helen Hobbs and Jonathan Cohen, at the University of Texas Southwestern Medical Center, Dallas, has provided new insight into how genetic variation can cause different individuals to have distinct levels of a fat known as triglyceride in their blood.

Related Articles


Results of their study appear online Dec. 15 in the Journal of Clinical Investigation.

The team focused on a family of genes known as ANGPTL genes and analyzed three family members (ANGPTL3, ANGPTL5, and ANGPT6L) in over 3,000 individuals. Several rare variations in the ANGPTL3 and ANGPTL5 genes were identified in individuals with low triglyceride levels in their blood and no other detectable defects in handling fats.

Previous studies have indicated a similar finding for ANGPTL4. Further analysis revealed that the ANGPTL3, ANGPTL4, and ANGPTL5 variants associated with low triglyceride levels in the blood generated proteins that had lost their normal function.

The team therefore conclude that variation in the ANGPTL3, ANGPTL4, and ANGPT6L genes contributes to the diversity of triglyceride levels in the blood of different individuals.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Romeo et al. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI37118

Cite This Page:

Journal of Clinical Investigation. "Your Genetic Make-up Influences The Levels Of Fats In Your Blood." ScienceDaily. ScienceDaily, 23 December 2008. <www.sciencedaily.com/releases/2008/12/081217200648.htm>.
Journal of Clinical Investigation. (2008, December 23). Your Genetic Make-up Influences The Levels Of Fats In Your Blood. ScienceDaily. Retrieved April 2, 2015 from www.sciencedaily.com/releases/2008/12/081217200648.htm
Journal of Clinical Investigation. "Your Genetic Make-up Influences The Levels Of Fats In Your Blood." ScienceDaily. www.sciencedaily.com/releases/2008/12/081217200648.htm (accessed April 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, April 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins