Featured Research

from universities, journals, and other organizations

Don't Scratch That Itch: Blocking The Protein IL-21R Helps Prevent A Form Of Eczema

Date:
December 31, 2008
Source:
Journal of Clinical Investigation
Summary:
Researchers have identified a role for the protein IL-21R in a mouse model of atopic dermatitis, a common allergic inflammatory skin disease often known as eczema.

Raif Geha and colleagues, at Children's Hospital, Boston, have identified a role for the protein IL-21R in a mouse model of atopic dermatitis, a common allergic inflammatory skin disease often known as eczema.

Results of their study appear online Dec. 15 in the Journal of Clinical Investigation.

As analysis of affected skin from patients with atopic dermatitis showed increased expression of IL-21R and the soluble factor that binds to it (IL-21), the authors suggest that targeting the IL-21/IL-21R interaction in the skin might help prevent skin sensitization, and therefore atopic dermatitis.

In the study, expression of IL-21R and IL-21 was increased in affected skin from patients with atopic dermatitis and in mouse skin subjected to irritation. The importance of this was highlighted by the observation that mice lacking IL-21R and normal mice treated with a molecule that blocks the IL-21/IL-21R interaction did not develop inflammation resembling atopic dermatitis after skin irritation and exposure to an allergen.

Further analysis determined one mechanism underlying the central role of IL-21R in the mouse model of atopic dermatitis. Briefly, immune cells known as DCs in the skin did not migrate to local lymph nodes and activate other immune cells important for causing the allergic inflammatory response in the skin.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jin et al. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI32310

Cite This Page:

Journal of Clinical Investigation. "Don't Scratch That Itch: Blocking The Protein IL-21R Helps Prevent A Form Of Eczema." ScienceDaily. ScienceDaily, 31 December 2008. <www.sciencedaily.com/releases/2008/12/081217200746.htm>.
Journal of Clinical Investigation. (2008, December 31). Don't Scratch That Itch: Blocking The Protein IL-21R Helps Prevent A Form Of Eczema. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2008/12/081217200746.htm
Journal of Clinical Investigation. "Don't Scratch That Itch: Blocking The Protein IL-21R Helps Prevent A Form Of Eczema." ScienceDaily. www.sciencedaily.com/releases/2008/12/081217200746.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins