Dec. 23, 2008 Rube Goldberg—the cartoonist who devised complex machines for simple tasks—would have smiled at one of leptin's mechanisms for curbing insulin release. A new study boosts researchers' hopes of using osteocalcin to treat diabetes. As Hinoi et al. show, the fat-derived hormone enlists the sympathetic nervous system to prevent bone-making cells from releasing a molecule that prods the pancreas to discharge insulin.
In the fight against obesity and diabetes, leptin is one of the good guys. Mice lacking the hormone become corpulent, and their sky-high insulin levels eventually lead to diabetes. Leptin can curtail insulin release directly. But there's also a back-door route that researchers are still trying to piece together. Scientists knew that leptin nudges osteoblasts, cells known for building bone but that also manufacture osteocalcin, a protein that stimulates insulin release. Hinoi et al. tested whether leptin acts on the pancreas through osteocalcin.
Leptin channels many of its effects through the nervous system. The team thus tested whether the hormone relied on the sympathetic nervous system, the branch that pumps out adrenaline during emergencies but at other times emits a hormonal trickle to maintain a low level of stimulation. This baseline activity was lower in mice lacking the leptin receptor, indicating a connection between leptin and the sympathetic nervous system. When that connection was broken by deleting the adrenaline receptor from mice osteoblasts, insulin levels shot up.
The researchers then dosed mice with a sympathetic stimulator. Rodents lacking leptin or the adrenaline receptor on their osteoblasts turned out normal amounts of osteocalcin, but much of it was in an inert form. That result suggests leptin affects insulin release by indirectly inactivating osteocalcin. The work boosts researchers' hopes of using osteocalcin to treat diabetes—a possibility some drug companies have already started to investigate.
Journal reference: Hinoi, E., et al. 2008. J. Cell Biol. doi:10.1083/jcb.200809113
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