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Inflammation Contributes to Colon Cancer

Date:
January 15, 2009
Source:
American Journal of Pathology
Summary:
Researchers found that mice that lack the immune inhibitory molecule Smad3 are acutely sensitive to both bacterially-induced inflammation and cancer.

Researchers led by Dr. Brian Iritani at The University of Washington found that mice that lack the immune inhibitory molecule Smad3 are acutely sensitive to both bacterially-induced inflammation and cancer.

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Bacteria contribute to the development of certain cancers, in some measure, by stimulating chronic inflammation. Absence of a molecule that inhibits inflammation, Smad3, may therefore increase susceptibility to colon cancer.

To examine whether Smad3 signaling contributes to development of colon cancer, Maggio-Price et al examined mice deficient in Smad3 that lack of adaptive immune responses. They found that these mice are acutely sensitive to bacterially-induced inflammation and cancer due to both deficient T regulatory cell function and increased expression of proinflammatory cytokines. Through increased expression of both pro-oncogenic and anti-apoptotic proteins, epithelial cells in colonic tissues underwent both enhanced proliferation and survival.

"That the inflammatory response to microorganisms is a key event in these results reveals important 'tumor-suppressive' functions for Smad3 in T effector cells, T regulatory cells, and intestinal epithelial cells, all of which may normally limit the development of colon cancer in response to bacterial inflammation," explains Dr. Iritani's group.


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maggio-Price L, Treuting P, Bielefeldt-Ohmann H, Seamons A, Drivdahl R, Zeng W, Lai L-H, Huycke M, Phelps S, Brabb T1, Iritani BM. Bacterial infection of Smad3/Rag2 double-null mice with TGF beta dysregulation as a model for studying inflammation-associated colon cancer. Am J Pathol, 2009, 174:317-329

Cite This Page:

American Journal of Pathology. "Inflammation Contributes to Colon Cancer." ScienceDaily. ScienceDaily, 15 January 2009. <www.sciencedaily.com/releases/2008/12/081230072246.htm>.
American Journal of Pathology. (2009, January 15). Inflammation Contributes to Colon Cancer. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2008/12/081230072246.htm
American Journal of Pathology. "Inflammation Contributes to Colon Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/12/081230072246.htm (accessed March 29, 2015).

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