Featured Research

from universities, journals, and other organizations

Nerve Cells In The Brain And Spinal Cord Sense Pain Caused By Physical Insult

Date:
January 9, 2009
Source:
Journal of Clinical Investigation
Summary:
Researchers have shown that the protein COX2 in mouse nerve cells in the central nervous system (CNS) is crucial for hypersensitivity to pain caused by the physical insult associated with inflammation, but not pain caused by the heat associated with inflammation. As pain caused by physical insult is a major symptom of postoperative and arthritic inflammation, it seems that COX2 in nerve cells in the CNS is central to the pain that accompanies these conditions.

Researchers have shown that the protein COX2 in mouse nerve cells in the central nervous system (CNS) is crucial for hypersensitivity to pain caused by the physical insult associated with inflammation, but not pain caused by the heat associated with inflammation. As pain caused by physical insult is a major symptom of postoperative and arthritic inflammation, it seems that COX2 in nerve cells in the CNS is central to the pain that accompanies these conditions.

The most common way of managing the pain that accompanies inflammation is to use drugs such as aspirin and ibuprofen.

These work by selectively blocking the protein COX2, which functions to produce soluble molecules known as prostaglandins. Although it is known that blocking COX2 in the tissue and in the brain and spinal cord (the CNS) reduces the pain that accompanies inflammation, the relative contribution of COX2 at these two sites to the pain that accompanies inflammation has not been determined.

However, a team of researchers, at Massachusetts General Hospital, Boston, and University of Pennsylvania, Philadelphia, have now shown that COX2 in mouse nerve cells in the CNS is crucial for some forms of pain associated with inflammation but not others. Specifically, hypersensitivity to pain caused by the heat associated with inflammation was normal in mice lacking COX2 in nerve cells in the CNS.

By contrast, hypersensitivity to pain caused by the physical insult associated with inflammation was abolished in these mice. As pain caused by physical insult is a major symptom of postoperative and arthritic inflammation, it seems that COX2 in nerve cells in the CNS is central to the pain that accompanies these conditions.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. Journal of Clinical Investigation, Jan 6, 2009

Cite This Page:

Journal of Clinical Investigation. "Nerve Cells In The Brain And Spinal Cord Sense Pain Caused By Physical Insult." ScienceDaily. ScienceDaily, 9 January 2009. <www.sciencedaily.com/releases/2009/01/090105175019.htm>.
Journal of Clinical Investigation. (2009, January 9). Nerve Cells In The Brain And Spinal Cord Sense Pain Caused By Physical Insult. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/01/090105175019.htm
Journal of Clinical Investigation. "Nerve Cells In The Brain And Spinal Cord Sense Pain Caused By Physical Insult." ScienceDaily. www.sciencedaily.com/releases/2009/01/090105175019.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins