Featured Research

from universities, journals, and other organizations

New Molecule In Blood-pressure Control System Discovered

Date:
January 10, 2009
Source:
Oregon Health & Science University
Summary:
Researchers have discovered that the nerve cells controlling heart rate and blood pressure synthesize a molecule known to be critically important for proper nervous system growth. The finding could someday play a significant role in the prevention of sudden infant death syndrome and high blood pressure.

Researchers at Oregon Health & Science University's School of Dentistry have discovered that the nerve cells controlling heart rate and blood pressure synthesize a molecule known to be critically important for proper nervous system growth.

The finding could someday play a significant role in the prevention of Sudden Infant Death Syndrome (SIDS) and high blood pressure. According to the National Institutes of Health, SIDS is the leading cause of death in children between 1 month and 1 year of age. About one in three adults in the United States has high blood pressure.

The new discovery was published in a January issue of the Journal of Neurochemistry (vol. 108, pp. 450-464) and released online December 1, 2008.

"Our discovery sheds light on how the nerve supply to the cardiovascular system is established during development," said Agnieszka Balkowiec, M.D., Ph.D., principal investigator, OHSU School of Dentistry assistant professor of integrative biosciences and OHSU School of Medicine adjunct assistant professor of physiology and pharmacology. "Someday we hope to better understand cardiorespiratory developmental disorders such as SIDS."

Changes in blood pressure are signaled to the brain by nerve cells called baroreceptors. The OHSU study shows that baroreceptors make a molecule called Brain-Derived Neurotrophic Factor (BDNF), which belongs to the family of neurotrophins that play a critical role in the development and plasticity of other nerve cells. (Studies suggest that developmental abnormalities in nerve pathways that control the cardiovascular and respiratory system may result in SIDS).

Balkowiec and her team found that the stimulation of baroreceptors, as experienced during an increase in blood pressure, leads to the release of BDNF. The study also discovered that BDNF is present at the central end of baroreceptors in the brainstem.

"In fact, BDNF is likely to play the most important role at the central end of baroreceptors, where they connect to second-order neurons in the blood-pressure control pathway," said Balkowiec. "BDNF has previously been shown to play an important role in establishing neuronal connections in other parts of the nervous system, but this is the first time it has been considered a factor in the blood pressure control system."

Studies under way, in collaboration with Virginia Brooks, Ph.D., OHSU School of Medicine professor of physiology and pharmacology, indicate that levels of BDNF in cardiorespiratory nerve cells increase dramatically when blood pressure rises. This suggests a direct role of BDNF in regulation of blood pressure, said Balkowiec.

Additional study authors include neuroscience graduate student Jessica Martin, B.S., and two OHSU research assistants, Victoria Jenkins, B.A., and Hui-ya Hsieh, B.S.

The study was supported by grants from the American Heart Association and the National Institute's of Health's National Heart, Lung, and Blood Institute.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "New Molecule In Blood-pressure Control System Discovered." ScienceDaily. ScienceDaily, 10 January 2009. <www.sciencedaily.com/releases/2009/01/090108141207.htm>.
Oregon Health & Science University. (2009, January 10). New Molecule In Blood-pressure Control System Discovered. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/01/090108141207.htm
Oregon Health & Science University. "New Molecule In Blood-pressure Control System Discovered." ScienceDaily. www.sciencedaily.com/releases/2009/01/090108141207.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins