Featured Research

from universities, journals, and other organizations

Better MRI Scans Of Cancers Now Possible

Date:
January 16, 2009
Source:
Delft University of Technology
Summary:
Researchers have developed a substance that enables doctors to get better MRI scans of tumors. The medical profession’s ability to trace and visualize tumors is increasing all the time. Detection and imaging techniques have improved enormously in recent years. One of the techniques that have come on by leaps and bounds is MRI. Patients who are going to have MRI scans are often injected with a ‘contrast agent’, which makes it easier to distinguish tumors from surrounding tissues.

Researcher Kristina Djanashvili has developed a substance that enables doctors to get better MRI scans of tumours.

Related Articles


The medical profession’s ability to trace and visualise tumours is increasing all the time. Detection and imaging techniques have improved enormously in recent years. One of the techniques that have come on by leaps and bounds is MRI. Patients who are going to have MRI scans are often injected with a ‘contrast agent’, which makes it easier to distinguish tumours from surrounding tissues. The quality of the resulting scan depends partly on the ability of this agent to ‘search out’ the tumour and induce contrast.

Better images

At TU Delft, postgraduate researcher Kristina Djanashvili has developed a new contrast agent with enhanced tumour affinity and contrast induction characteristics. In principle, this means that cancers can be picked up sooner and visualised more accurately.

The new agent is a compound incorporating a lanthanide chelate and a phenylboronate group substance. The lanthanide chelate ensures a strong, clear MRI signal, while the phenylboronate group substance ‘searches out’ cancerous tissue.

Water exchange

The lanthanide chelate influences the behaviour of water molecules, even inside the human body. It is ultimately the behaviour of the hydrogen nuclei in the water molecules that makes MRI possible and determines the quality of the image produced. The stronger the influence of the lanthanide chelate on the neighbouring hydrogen nuclei (the so-called water exchange) and the more hydrogen nuclei affected, the better the MRI signal obtained. Djanashvili has defined the methods for determining the water exchange parameters.

Sugar

Djanashvili has also provided her contrast agent with enhanced tumour-seeking properties by including a phenylboronate group substance. Phenylboronate has an affinity with certain sugary molecules that tend to concentrate on the surface of tumour cells. What makes the selected phenylboronate-containing agent special is its ability to chemically bond with the surface of a tumour cell.

Mice

Finally, Djanashvili has managed to incorporate the compound into so-called thermosensitive liposomes. A thermosensitive liposome forms a sort of protective ball, which opens (releasing the active compound) only when heated to roughly 42 degrees. This means that, by localised heating of a particular part of the body, it is possible to control where the compound is released. The positive results obtained from testing the new agent on mice open the way for further research.

On Tuesday 13 January, Djanashvili will be awarded a doctorate by TU Delft for her work in this field.


Story Source:

The above story is based on materials provided by Delft University of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Delft University of Technology. "Better MRI Scans Of Cancers Now Possible." ScienceDaily. ScienceDaily, 16 January 2009. <www.sciencedaily.com/releases/2009/01/090113074417.htm>.
Delft University of Technology. (2009, January 16). Better MRI Scans Of Cancers Now Possible. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2009/01/090113074417.htm
Delft University of Technology. "Better MRI Scans Of Cancers Now Possible." ScienceDaily. www.sciencedaily.com/releases/2009/01/090113074417.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins