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Protein That Amplifies Cell Death Discovered: Potentially A New Way To Kill Cancer Cells

Date:
January 16, 2009
Source:
Albert Einstein College of Medicine
Summary:
Scientists have identified a small intracellular protein that helps cells commit suicide. In response to stress or as a natural part of aging, many cells undergo programmed suicide, also known as apoptosis. Cancer cells often become immortal and dangerous by developing the ability to suppress apoptosis.

Expression of a small fragment of p115 (green) leads to Cytochrome C (red) release in cells causing cell death.
Credit: Albert Einstein College of Medicine

Scientists at Albert Einstein College of Medicine of Yeshiva University have identified a small intracellular protein that helps cells commit suicide. The finding could lead to drugs for combating cancer and other diseases characterized by overproduction of cells.

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The research was led by the late Dennis Shields, Ph.D., a professor in Einstein's Department of Developmental and Molecular Biology for 30 years, who died unexpectedly in December.

In response to stress or as a natural part of aging, many cells undergo programmed suicide, also known as apoptosis. Cancer cells often become immortal and dangerous by developing the ability to suppress apoptosis.

A decade ago apoptosis was thought to be directed solely by the nucleus and mitochondria of cells. Dr. Shields' laboratory was the first to show that a cellular organelle known as the Golgi apparatus also plays a role in apoptosis.

The Golgi package proteins and other substances made by cells and direct them to their destination within the cell. A protein called p115 is vital for maintaining the structure of the Golgi. In earlier research, Dr. Shields' group demonstrated that the Golgi's p115 protein splits into two pieces early in apoptosis and that the smaller of these protein fragments—205 amino acids in length—helps to maintain the cell-suicide process.

In the present study, the Einstein researchers identified the smallest region of this p115 protein fragment that is required for apoptosis: a peptide of just 26 amino acids in length that exerts its apoptotic action by traveling to the nucleus.

"Dennis Shields was one of our most outstanding scientists," says E. Richard Stanley, Ph.D., chairman of developmental and molecular biology at Einstein. "His efforts to uncover fundamental mechanisms governing how cells work has led to new ways of thinking about apoptosis, in particular, how the Golgi regulates this process."


Story Source:

The above story is based on materials provided by Albert Einstein College of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mukherjee et al. Nuclear Import Is Required for the Pro-apoptotic Function of the Golgi Protein p115. Journal of Biological Chemistry, 2008; 284 (3): 1709 DOI: 10.1074/jbc.M807263200

Cite This Page:

Albert Einstein College of Medicine. "Protein That Amplifies Cell Death Discovered: Potentially A New Way To Kill Cancer Cells." ScienceDaily. ScienceDaily, 16 January 2009. <www.sciencedaily.com/releases/2009/01/090114172314.htm>.
Albert Einstein College of Medicine. (2009, January 16). Protein That Amplifies Cell Death Discovered: Potentially A New Way To Kill Cancer Cells. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/01/090114172314.htm
Albert Einstein College of Medicine. "Protein That Amplifies Cell Death Discovered: Potentially A New Way To Kill Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2009/01/090114172314.htm (accessed October 25, 2014).

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