Featured Research

from universities, journals, and other organizations

Lack Of Grey Matter In Brain Is Linked To Schizophrenia And Bipolar Disorder

Date:
January 19, 2009
Source:
Plataforma SINC
Summary:
Lack of grey matter in the brain is linked to schizophrenia and bipolar disorder. A new study shows that adolescents experiencing a first outbreak of psychosis have lower levels of gray matter in their brains than healthy teenagers. Strangely, this change was seen in patients suffering from various psychoses, including bipolar illness and schizophrenia.

A research study led by scientists from the Gregorio Maraρσn University Hospital in Madrid and the Network of Centres for Biomedical Research in Mental Health Networks (CIBERSAM) shows that adolescents experiencing a first outbreak of psychosis have lower levels of grey matter in their brains than healthy teenagers. Strangely, this change was seen in patients suffering from various psychoses, including bipolar illness and schizophrenia.

The objective of the study was to examine and locate differences in the volume of grey matter in the brains of healthy people (controls) and individuals diagnosed with psychotic outbreaks in infancy or adolescence. The researchers broke such psychosis down into three sub-groups – schizophrenia, bipolar disorder and other psychoses that did not fit into either of the other two classifications.

The study, published recently in the Journal of the American Academy of Child and Adolescent Psychiatry, analysed a sample of 121 people aged between 7 and 18, inclusive. All the patients and controls were examined using magnetic resonance imaging in order to detect any possible changes in the structure of their brains.

“The interesting thing was that we found common alterations among those with two types of clinically-differentiated psychoses, schizophrenia and bipolar disorder, and this could help to improve diagnosis of these illnesses,” Santiago Reig, one of the study’s authors and a researcher in the Medical Imaging Laboratory of the Gregorio Maraρσn Hospital, tells SINC.

The study confirmed these lower levels of grey matter, the brain substance in which neurone cells are concentrated. This lack, which was shared between the schizophrenia and type 1 bipolar illness sufferers, means the functions of this part of the brain are “somehow atrophied”.

In addition, the technique used by the experts can pinpoint the location of these alterations. For example, “patients with early psychotic outbreaks (before the age of 18) showed alterations in the medial prefrontal gyrus region of the brain, which controls processes such as cognition and the regulation of sensations”, says Reig.

Improving diagnosis

“Anything that helps to detect alterations shared between distinct pathologies can help in the development of drugs and in finding common characteristics between these different diseases,” the researcher tells SINC. “Results like these are fundamental for the diagnosis and treatment of illnesses,” he adds.

However, it is important not to draw any causal link between alterations in this area of the brain and the appearance of these pathologies. Psychiatric illnesses need more complex diagnosis. What the research does show, however, is that the majority of people with schizophrenia and type 1 bipolar illness do suffer from this lack of grey matter and the majority of healthy people have normal levels of this substance.

“We still do not know whether this loss of grey matter is caused by the illness or not,” says Reig. This is just one more piece of the puzzle to help in understanding common features of psychiatric illnesses. “Maybe relating these developments with other new findings will one day help us to solve the riddle of psychiatric illnesses,” he concludes.


Story Source:

The above story is based on materials provided by Plataforma SINC. Note: Materials may be edited for content and length.


Cite This Page:

Plataforma SINC. "Lack Of Grey Matter In Brain Is Linked To Schizophrenia And Bipolar Disorder." ScienceDaily. ScienceDaily, 19 January 2009. <www.sciencedaily.com/releases/2009/01/090116073803.htm>.
Plataforma SINC. (2009, January 19). Lack Of Grey Matter In Brain Is Linked To Schizophrenia And Bipolar Disorder. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2009/01/090116073803.htm
Plataforma SINC. "Lack Of Grey Matter In Brain Is Linked To Schizophrenia And Bipolar Disorder." ScienceDaily. www.sciencedaily.com/releases/2009/01/090116073803.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) — Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins