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How Toxoplasma Gondii Gets Noticed

Date:
January 19, 2009
Source:
Rockefeller University Press
Summary:
Researchers provide insight into how Toxoplasma gondii, a common parasite of people and other animals, triggers an immune response in its host.
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Researchers provide insight into how Toxoplasma gondii, a common parasite of people and other animals, triggers an immune response in its host.

A strong immune response spares T. gondii-infected hosts from deadly infection—an event that may also benefit the parasite, which relies on survival of the host to ensure its own transmission. But how the infected host elicits an immune response isn't completely understood.

Like many other parasites, T. gondii resides within specialized vesicles inside infected host cells, but the process by which peptides from the trapped bugs are processed by infected cells and presented to killer T cells is mysterious.

In new research, Romina Goldszmid and her colleagues at the National Institutes of Health in Bethesda use T. gondii infections in mice to study how portions of the parasitic proteins escape the vesicle in a process known as cross-presentation.

They find that the parasite gets noticed by the immune system when the membrane of the bug-containing vesicle fuses to the endoplasmic reticulum—an organelle normally involved in presenting pathogens to T cells—allowing a swap of parasitic peptides.

The report will appear online on January 19th in The Journal of Experimental Medicine.


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The above post is reprinted from materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


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Rockefeller University Press. "How Toxoplasma Gondii Gets Noticed." ScienceDaily. ScienceDaily, 19 January 2009. <www.sciencedaily.com/releases/2009/01/090119091053.htm>.
Rockefeller University Press. (2009, January 19). How Toxoplasma Gondii Gets Noticed. ScienceDaily. Retrieved August 28, 2015 from www.sciencedaily.com/releases/2009/01/090119091053.htm
Rockefeller University Press. "How Toxoplasma Gondii Gets Noticed." ScienceDaily. www.sciencedaily.com/releases/2009/01/090119091053.htm (accessed August 28, 2015).

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