Featured Research

from universities, journals, and other organizations

New Tools Can Better Predict Successful Kidney Transplant Outcomes

Date:
January 22, 2009
Source:
Elsevier Health Sciences
Summary:
Because of the shortage of deceased organ donors, living donor transplantation is rapidly growing, and has the advantage of improved outcomes over deceased donor transplants. A transplant candidate may now have several potential living donors; the clinician may need to identify which donor would yield the best results. Researchers now report on the development and validation of three nomograms that can reliably predict long-term outcomes.

Kidney transplants are the best available therapy for end stage renal disease. Because of the shortage of deceased organ donors, living donor transplantation is rapidly growing and has the advantage of improved outcomes over deceased donor transplants. In fact, a transplant candidate may now have several potential living donors and the clinician may need to identify which donor would yield the best results. In a study published in The Journal of Urology, researchers report on the development and validation of three nomograms that can reliably predict long-term outcomes.

Related Articles


A nomogram is an objective tool that uses an algorithm or mathematical formula to predict the probability of an outcome. Nomograms have been shown to outperform clinicians in predicting oncological outcomes and may be of benefit in certain decision-making settings. Nomograms can sift through the multitude of donor and recipient parameters that impact transplant outcome and help transplant physicians to better counsel their patients.

Using records from over 20,000 living donor transplant cases taken from the United Network for Organ Sharing (UNOS) registry, investigators from the Renal Transplantation Program, Glickman Urological & Kidney Institute at the Cleveland Clinic identified 18 characteristics, such as donor and recipient ages, donor serum creatinine levels and the cause of the recipient's renal failure. By using the value of each factor to determine a point score and totaling all of the points, the nomograms were able to predict kidney function 1 year after transplant and 5-year transplant survival. By adding 3 additional factors obtained 6 months after surgery, another nomogram was developed to refine the 5-year survival prediction.

Writing in the article, D. A. Goldfarb states, "Our work is consistent with the transplant physician community's efforts to develop better predictive tools...the nomograms developed in this study take this effort a step further by using a greater number of variables including early posttransplant information for better predictability and by attempting to predict specific outcome measures of renal function in addition to long term graft survival... These models can help to optimize the selection of living kidney donors. The prognostic information these models provide can help improve patient care."


Story Source:

The above story is based on materials provided by Elsevier Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. H.Y. Tiong, D.A. Goldfarb, M.W. Kattan, J.M. Alster, L. Thuita, C. Yu, A. Wee and E.D. Poggio. Nomograms for Predicting Graft Function and Survival in Living Donor Kidney Transplantation Based on the UNOS Registry. The Journal of Urology, Volume 181, Issue 3 (March 2009)

Cite This Page:

Elsevier Health Sciences. "New Tools Can Better Predict Successful Kidney Transplant Outcomes." ScienceDaily. ScienceDaily, 22 January 2009. <www.sciencedaily.com/releases/2009/01/090122080710.htm>.
Elsevier Health Sciences. (2009, January 22). New Tools Can Better Predict Successful Kidney Transplant Outcomes. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2009/01/090122080710.htm
Elsevier Health Sciences. "New Tools Can Better Predict Successful Kidney Transplant Outcomes." ScienceDaily. www.sciencedaily.com/releases/2009/01/090122080710.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins