Featured Research

from universities, journals, and other organizations

Is Rapid Transition Through Menopause Linked To Earlier Onset Of Heart Disease?

Date:
January 28, 2009
Source:
Cedars-Sinai Medical Center
Summary:
An evaluation of 203 women found that those who transitioned more quickly through menopause were at increased risk for a higher rate of progression of "preclinical atherosclerosis" -- narrowing of arteries caused by the thickening of their walls.

An evaluation of 203 women as part of the multifaceted Los Angeles Atherosclerosis Study (LAAS) found that those who transitioned more quickly through menopause were at increased risk for a higher rate of progression of "preclinical atherosclerosis" – narrowing of arteries caused by the thickening of their walls.

Related Articles


Cardiologist C. Noel Bairey Merz, M.D., is principal investigator of the study. She is director of the Women's Heart Center and the Preventive and Rehabilitative Cardiac Center at the Cedars-Sinai Heart Institute. She serves as professor of medicine at Cedars-Sinai and holds the Women's Guild Endowed Chair in Women's Health.

This observational study included 203 women between ages 45 and 60 at the time they entered the study. Fifty-two were premenopausal, 20 were perimenopausal and 131 were postmenopausal. None of the women had been diagnosed with cardiovascular disease. They were evaluated when they entered the study and at two 18-month intervals, providing a snapshot over a three-year period of time.

Evaluations included carotid intimal-media thickness (cIMT) measurements and objective measures of menopausal status based on hormone levels and physiologic changes, not subjective factors, such as hot flashes and estimates of menstrual cycling.

Women who transitioned from being premenopausal to being fully postmenopausal within three years had more buildup of fatty plaque in their carotid arteries, suggesting that women who transition through menopause rapidly are at greater risk of early development of heart disease.

"We know that more fatty plaque accumulation predicts future heart attacks and strokes, but this is our first venture into this particular line of inquiry. This is an observational study, which doesn't provide specific recommendations for patient evaluation and treatment, but it does raise questions," Bairey Merz said.

"The findings suggest that we study this more definitively to possibly determine if women undergoing a more rapid menopause might benefit from early hormone replacement therapy," she said. "In the meantime, physicians could consider using carotid intimal-media thickness measurement or other cardiovascular screenings for women who are rapidly transitioning or who have certain risk factors, such as cigarette smoking or chemotherapy, which are known to accelerate transition through the menopause."

The study should not be used by patients to self-diagnose or presume they may be at higher risk because of symptoms.

"Women will say they're perimenopausal because they're having hot flashes or sleep disturbances or some cycle irregularity, but those are all symptoms. We use a very specific code of definitions to assess hormones and whether or not the ovaries are cycling," Bairey Merz said, adding that all women from the age of 21 should have annual checkups, which include blood pressure, cholesterol, height, weight and other measurements. Those at increased risk for cardiovascular disease may be referred by their physicians for additional screenings.

Funding for this study was provided by a grant from the National Institutes of Health/National Heart, Lung, and Blood Institute.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Is Rapid Transition Through Menopause Linked To Earlier Onset Of Heart Disease?." ScienceDaily. ScienceDaily, 28 January 2009. <www.sciencedaily.com/releases/2009/01/090127165945.htm>.
Cedars-Sinai Medical Center. (2009, January 28). Is Rapid Transition Through Menopause Linked To Earlier Onset Of Heart Disease?. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2009/01/090127165945.htm
Cedars-Sinai Medical Center. "Is Rapid Transition Through Menopause Linked To Earlier Onset Of Heart Disease?." ScienceDaily. www.sciencedaily.com/releases/2009/01/090127165945.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins