Featured Research

from universities, journals, and other organizations

Umbilical Cord Protein Analysis Detects Early Onset Infection

Date:
January 30, 2009
Source:
Yale University
Summary:
Researchers have identified proteins associated with early onset neonatal sepsis (EONS), a stealthy bacterial infection linked to premature birth, illness and death. Using protein analysis, the researchers have found the biomarkers that can provide key information on how EONS develops.

Yale School of Medicine researchers have identified proteins associated with early onset neonatal sepsis (EONS), a stealthy bacterial infection linked to premature birth, illness and death. Using protein analysis, the researchers have found the biomarkers that can provide key information on how EONS develops.

Related Articles


"The biomarkers we identified have diagnostic value for infection and inflammation," said Yale assistant professor Catalin Buhimschi, M.D., senior investigator on the study who presented the findings in an abstract at the Society for Maternal Fetal Medicine (SMFM) conference in San Diego, Calif. "We have identified changes that occur in the physiology of the fetus that is exposed to infection and inflammation in the amniotic fluid."

Premature births accounts for 75 percent of infant mortality and 50 percent of long-term handicaps, including blindness, deafness, bronchopulmonary dysplasia, developmental delay and cerebral palsy. The poor outcome is not entirely dependent on their gestational age at birth but rather on other processes such as early onset neonatal sepsis. EONS is extremely difficult to diagnose. At-risk pregnant women are currently treated with a dose of antibiotics before delivery. At birth, the babies are treated with yet another round of antibiotics. These antibiotics can mask the presence of EONS, leading to false negative bacterial culture test results and development of antibiotic resistance.

Buhimschi said that the Yale team's work might lead to earlier identification of EONS, so that only babies who need treatment receive antibiotics.

Buhimschi and his team analyzed protein in the cord blood of 155 preterm babies to identify which physiological pathways in the protein are activated in EONS. They used a technique called fluorescence 2-D differential gel electrophoresis (2D-DIGE) to create a map of the biomarkers in fetuses that have sepsis. They then observed how the proteins match in physiological pathways.

"We found that early onset neonatal sepsis is characterized by a variety of biomarkers that have different functions," said Buhimschi. "These biomarkers tell us how the fetus reacts to infection by giving a better map of a baby's physiology."

"We hope this research will lead to identifying babies who will develop EONS so that we can prevent its potentially devastating effects," Buhimschi added.

The National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development funded the study.

Other authors on the study are Vineet Bhandari, M.D., Antonette T. Dulay, M.D., Sarah Lee, M.D., Guomao Zhao, Christian M. Pettker, M.D., Sonya S. Abdel-Razeq, M.D., Stephen Thung, M.D., Yiping Han and Irina Buhimschi, M.D.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Umbilical Cord Protein Analysis Detects Early Onset Infection." ScienceDaily. ScienceDaily, 30 January 2009. <www.sciencedaily.com/releases/2009/01/090129113316.htm>.
Yale University. (2009, January 30). Umbilical Cord Protein Analysis Detects Early Onset Infection. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/01/090129113316.htm
Yale University. "Umbilical Cord Protein Analysis Detects Early Onset Infection." ScienceDaily. www.sciencedaily.com/releases/2009/01/090129113316.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins