Featured Research

from universities, journals, and other organizations

Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance

Date:
February 3, 2009
Source:
Journal of Clinical Investigation
Summary:
Individuals who are obese have an increased risk of developing type 2 diabetes, in part because they often become resistant to the effects of the hormone insulin. Resistin is a soluble factor produced by fat cells (adipocytes) that is linked to the development of insulin resistance in mice. However, studies have thus far failed to determine such a clear association in humans. But now, researchers have determined that human resistin contributes to the development of insulin resistance in mice.

Individuals who are obese have an increased risk of developing type 2 diabetes, in part because they often become resistant to the effects of the hormone insulin. Resistin is a soluble factor produced by fat cells (adipocytes) that is linked to the development of insulin resistance in mice. However, studies have thus far failed to determine such a clear association in humans.

Related Articles


But now, Mitchell Lazar and colleagues, at the University of Pennsylvania, Philadelphia, have determined that human resistin contributes to the development of insulin resistance in mice.

The research appears online, Feb. 2nd, 2009, in the Journal of Clinical Investigation.

One factor that has complicated studies attempting to determine the role of resistin in the development of insulin resistance in humans, is that resistin is produced mainly by immune cells known as macrophages in humans, whereas it is produced by adipocytes in mice.

To overcome this issue, the authors generated mice lacking mouse resistin and expressing human resistin in macrophages. When these mice were fed a high-fat diet, they developed inflammation of the fat tissue, which led to altered levels of fats in the blood and, ultimately, to insulin resistance.

It is hoped that future studies using these mice will help determine the therapeutic potential of modulating levels of human resistin.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mohammed Qatanani, Nava R. Szwergold, David R. Greaves, Rexford S. Ahima, Mitchell A. Lazar. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J. Clin. Invest., 2009; DOI: 10.1172/JCI37273

Cite This Page:

Journal of Clinical Investigation. "Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance." ScienceDaily. ScienceDaily, 3 February 2009. <www.sciencedaily.com/releases/2009/02/090202174701.htm>.
Journal of Clinical Investigation. (2009, February 3). Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2009/02/090202174701.htm
Journal of Clinical Investigation. "Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance." ScienceDaily. www.sciencedaily.com/releases/2009/02/090202174701.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins