Featured Research

from universities, journals, and other organizations

Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance

Date:
February 3, 2009
Source:
Journal of Clinical Investigation
Summary:
Individuals who are obese have an increased risk of developing type 2 diabetes, in part because they often become resistant to the effects of the hormone insulin. Resistin is a soluble factor produced by fat cells (adipocytes) that is linked to the development of insulin resistance in mice. However, studies have thus far failed to determine such a clear association in humans. But now, researchers have determined that human resistin contributes to the development of insulin resistance in mice.

Individuals who are obese have an increased risk of developing type 2 diabetes, in part because they often become resistant to the effects of the hormone insulin. Resistin is a soluble factor produced by fat cells (adipocytes) that is linked to the development of insulin resistance in mice. However, studies have thus far failed to determine such a clear association in humans.

Related Articles


But now, Mitchell Lazar and colleagues, at the University of Pennsylvania, Philadelphia, have determined that human resistin contributes to the development of insulin resistance in mice.

The research appears online, Feb. 2nd, 2009, in the Journal of Clinical Investigation.

One factor that has complicated studies attempting to determine the role of resistin in the development of insulin resistance in humans, is that resistin is produced mainly by immune cells known as macrophages in humans, whereas it is produced by adipocytes in mice.

To overcome this issue, the authors generated mice lacking mouse resistin and expressing human resistin in macrophages. When these mice were fed a high-fat diet, they developed inflammation of the fat tissue, which led to altered levels of fats in the blood and, ultimately, to insulin resistance.

It is hoped that future studies using these mice will help determine the therapeutic potential of modulating levels of human resistin.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mohammed Qatanani, Nava R. Szwergold, David R. Greaves, Rexford S. Ahima, Mitchell A. Lazar. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J. Clin. Invest., 2009; DOI: 10.1172/JCI37273

Cite This Page:

Journal of Clinical Investigation. "Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance." ScienceDaily. ScienceDaily, 3 February 2009. <www.sciencedaily.com/releases/2009/02/090202174701.htm>.
Journal of Clinical Investigation. (2009, February 3). Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/02/090202174701.htm
Journal of Clinical Investigation. "Resistin Arrest: New Approach Shows Human Resistin Contributes To Insulin Resistance." ScienceDaily. www.sciencedaily.com/releases/2009/02/090202174701.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins