Featured Research

from universities, journals, and other organizations

Healthy People With High Urinary Protein Levels Have Elevated Kidney Disease Risk

Date:
February 13, 2009
Source:
American Society of Nephrology
Summary:
Measuring the amount of protein lost in the urine can identify individuals at risk of developing kidney disease, according to a new study. The results suggest that a simple and low-cost urine screen is a promising way to address the epidemic of chronic kidney disease.

Measuring the amount of protein lost in the urine can identify individuals at risk of developing kidney disease, according to a new study. The results suggest that a simple and low-cost urine screen is a promising way to address the epidemic of chronic kidney disease (CKD).

Related Articles


More and more individuals are diagnosed with CKD each year, but many people are unaware of their risks of developing the disease. Researchers have been looking for ways to screen the population to identify people at high risk for kidney function loss at an early stage so that preventive measures can be taken. Now investigators have found that screening urine samples is a promising strategy.

In a study led by Ronald T. Gansevoort, MD, PhD, of the University Medical Center Groningen in the Netherlands, more than 40,000 individuals of the general population were asked to collect a urine sample in a plastic test tube. Samples were sent to a central laboratory where their protein concentrations were measured. The investigators continued to follow these individuals and noted who developed end-stage kidney disease over the next nine years. A subgroup of 8,592 subjects visited an outpatient department once every three years allowing a detailed study of the rate of kidney function decline during follow-up.

Subjects from the general population that were found to have increased urinary protein levels were shown to represent more than half of the patients who started dialysis or had a kidney transplant during follow-up. Restricting screening to those individuals with hypertension, diabetes, cardiovascular disease history, or age >55 years having increased urinary protein levels identified nearly all cases needing kidney disease treatment during follow-up.

The researchers concluded that individuals with high urinary protein levels are at high risk for losing their kidney function and needing dialysis or a kidney transplant. The higher the level of proteins in the urine, the higher the risk of needing dialysis or a kidney transplant and the more rapid the rate of kidney function decline.

"Our findings suggest that subjects with a high amount of urinary protein loss should be invited to a medical center for further investigation and for start of preventive treatment to protect the kidney," said Dr. Gansevoort. While our group already showed this approach to be cost-effective to prevent cardiovascular events, additional studies are needed to determine if performing urine screens in the general population (or in certain high-risk groups of individuals) would even be more cost-effective because need for dialysis may also be prevented.

The PREVEND study was made possible by grants from the Dutch Kidney Foundation. The funding for this study had no role in its design, conduct, analysis, or in the decision to submit the study for publication.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Screening for Albuminuria Identifies Individuals at Increased Renal Risk. Journal of the American Society Nephrology, Online February 11, 2009; In print April 2009 DOI: 10.1681/ASN.2008060655

Cite This Page:

American Society of Nephrology. "Healthy People With High Urinary Protein Levels Have Elevated Kidney Disease Risk." ScienceDaily. ScienceDaily, 13 February 2009. <www.sciencedaily.com/releases/2009/02/090211193805.htm>.
American Society of Nephrology. (2009, February 13). Healthy People With High Urinary Protein Levels Have Elevated Kidney Disease Risk. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2009/02/090211193805.htm
American Society of Nephrology. "Healthy People With High Urinary Protein Levels Have Elevated Kidney Disease Risk." ScienceDaily. www.sciencedaily.com/releases/2009/02/090211193805.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins