Featured Research

from universities, journals, and other organizations

New Platinum-based Anti-tumor Compound Developed

Date:
February 21, 2009
Source:
Wake Forest University
Summary:
Researchers have developed a new class of platinum-based anti-tumor drugs that animal studies have shown to be 10 times more effective than current treatments in destroying certain types of lung cancer cells.

Researchers in the Department of Chemistry at Wake Forest University in collaboration with colleagues at the Wake Forest University Health Sciences Comprehensive Cancer Center have developed a new class of platinum-based anti-tumor drugs that animal studies have shown to be 10 times more effective than current treatments in destroying certain types of lung cancer cells.

Related Articles


The results were published in the December 11 issue of the Journal of Medicinal Chemistry and highlighted in Science-Business eXchange (SciBX), produced by Nature Publishing Group and BioCentury Publications, Inc. They suggest a new approach to fighting non-small cell lung cancer, which accounts for more than three-quarters of all lung cancers. Lung cancer is the leading cause of cancer-related deaths in both men and women. Less than a third of non-small cell lung cancer patients respond to traditional platinum-based therapies, and those who do respond have a median survival of less than a year.

“We are able to slow the growth of this cancer substantially in mice,” said principal investigator Ulrich Bierbach, Z. Smith Reynolds Foundation Fellow and associate professor of chemistry at Wake Forest. “That is very good news, since this is such a rapidly growing, intractable type of cancer.”

The new compound’s potency derives from its ability to rapidly bind with and disable a tumor cell’s DNA before the cell’s natural repair mechanisms are activated. That repair process causes drug resistance, which reduces the effectiveness of currently used platinum-based drugs.

Bierbach has focused his research efforts since 1992 on finding ways to overcome the resistance problems inherent in platinum-based drugs. He joined the Wake Forest faculty in 1999, and since 2001, has led a research team that included participation by eight graduate students and more than 30 undergraduate students. The recent paper marks the 25th he has published on the topic.

“If this ends up in clinical trials in the next few years, that will fulfill a dream of mine,” Bierbach said.

His research efforts will now be directed toward finding ways to boost the tumor-killing potency of the new compounds while reducing harmful side effects.

The new hybrid compounds are available for licensing from the Wake Forest University Office of Technology Asset Management.


Story Source:

The above story is based on materials provided by Wake Forest University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zhidong Ma, Jayati Roy Choudhury, Marcus W. Wright, Cynthia S. Day, Gilda Saluta, Gregory L. Kucera, Ulrich Bierbach. A Non-Cross-Linking Platinum-Acridine Agent with Potent Activity in Non-Small-Cell Lung Cancer. Journal of Medicinal Chemistry, 2008; 51 (23): 7574 DOI: 10.1021/jm800900g

Cite This Page:

Wake Forest University. "New Platinum-based Anti-tumor Compound Developed." ScienceDaily. ScienceDaily, 21 February 2009. <www.sciencedaily.com/releases/2009/02/090211193818.htm>.
Wake Forest University. (2009, February 21). New Platinum-based Anti-tumor Compound Developed. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2009/02/090211193818.htm
Wake Forest University. "New Platinum-based Anti-tumor Compound Developed." ScienceDaily. www.sciencedaily.com/releases/2009/02/090211193818.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins