Featured Research

from universities, journals, and other organizations

HIV Antiretroviral Medications Linked To Heart Attacks

Date:
February 13, 2009
Source:
Dublin, University College
Summary:
New research findings help explain why some HIV patients treated with antiretroviral medications experience increased incidence of heart attacks.

New research findings help explain why some HIV patients treated with antiretroviral medications experience increased incidence of heart attacks.

Related Articles


The late-braking data was presented by researchers from the School of Medicine and Medical Sciences at University College Dublin, the Mater Misericordiae University Hospital in Dublin, and the Royal College of Surgeons in Ireland at the Retrovirus Conference in Montreal, Canada, on 11 February 2009.

A major international study, published in 2008, identified a higher than expected incidence of heart attacks among patients being treated with antiretroviral drugs for HIV. Building on this research, scientists at the Royal College of Surgeons in Ireland developed a novel assay (test) tied to HIV to measure platelet activity in blood.  Platelets are essential for blood clotting when the skin is broken but, if they are dysfunctional within the bloodstream, they can cause clots within arteries which lead to heart attacks.

Using this new test, the team from University College Dublin and the Mater Misericordiae University Hospital in Dublin, undertook clinical trials to investigate the activity of platelets among HIV patients in Dublin, Ireland. These findings show a significant increase in platelet reactivity among patients taking certain antiretroviral medications.

‘These findings will significantly affect the management of patients with HIV and have important implications for the treatment of HIV worldwide,” says Dr Paddy Mallon, consultant in Infectious Diseases at the Mater Misericordiae University Hospital in Dublin and a lecturer in medicine at University College Dublin, who leads the group researching drug toxicities in HIV.

“The international research published last year showed the link between antiretroviral treatments and increased risk of heart attacks but not the reason why.  We have now demonstrated that the use of certain drugs for HIV has a direct effect on platelets within the blood.  The results provide invaluable information to help in the search for safe long term therapies for HIV infection.”

Professor Dermot Kenny from the Royal College of Surgeons in Ireland, whose group developed the novel assay, said that the results of this trial demonstrated the value of translational research.  “Because of our close collaboration we have seen how the novel diagnostics developed in our lab can move rapidly into the clinic in Ireland.  We plan to extend this research to other HIV centres internationally.”


Story Source:

The above story is based on materials provided by Dublin, University College. Note: Materials may be edited for content and length.


Cite This Page:

Dublin, University College. "HIV Antiretroviral Medications Linked To Heart Attacks." ScienceDaily. ScienceDaily, 13 February 2009. <www.sciencedaily.com/releases/2009/02/090212094042.htm>.
Dublin, University College. (2009, February 13). HIV Antiretroviral Medications Linked To Heart Attacks. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/02/090212094042.htm
Dublin, University College. "HIV Antiretroviral Medications Linked To Heart Attacks." ScienceDaily. www.sciencedaily.com/releases/2009/02/090212094042.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins