Featured Research

from universities, journals, and other organizations

Surprising Interactions Of Diabetes Mellitus And Sepsis

Date:
February 22, 2009
Source:
BioMed Central/Critical Care
Summary:
Diabetic patients are less likely to suffer from acute respiratory failure during severe sepsis. Researchers studied 930 million hospitalizations over a 25-year period to investigate the protective effect, adding to our knowledge of both diabetes and sepsis.

Diabetic patients are less likely to suffer from acute respiratory failure during severe sepsis. Researchers writing in BioMed Central's open access journal Critical Care studied 930 million hospitalisations over a 25-year period to investigate the protective effect, adding to our knowledge of both diabetes and sepsis.

Drs. Annette Esper and Greg Martin from Emory University in Atlanta, Georgia worked with a team of researchers to investigate suspected links between diabetes mellitus (DM) and the likelihood of experiencing different kinds of organ dysfunction during sepsis. He said, "We've found that people with DM and sepsis were more likely to develop acute renal failure than people without DM, while being less likely to develop acute respiratory failure. Findings like these are important, as accurate identification of populations at risk for different acute organ dysfunctions is crucial to the development of novel therapies for these patients."

According to the Surviving Sepsis Campaign, it is estimated that 1,400 people die each day from sepsis. DM is an increasingly common illness, believed to afflict as much as 7% of the population of the US. The authors found that among patients with a respiratory source of sepsis, 16% of those with DM developed acute respiratory failure compared with 23% in people without DM. Among patients with a non-pulmonary source of sepsis, those with DM were still less likely to develop acute respiratory failure when compared with those without DM (6% vs. 10%).

Speculating upon possible reasons for the discrepancy, Martin said, "Possible mechanisms of protection in patients with DM may be impaired neutrophil function or altered neutrophil-endothelial interactions. Alternatively, patients with DM may be hospitalised earlier in the course of their illness than those with no DM because they learn to be aware of specific signs of infection. Finally, pharmacological aspects of DM care may also influence the development of organ dysfunction, because many medications administered to patients with DM, including insulin and thiazolidinediones, are known to have anti-inflammatory effects in addition to lowering blood glucose."


Story Source:

The above story is based on materials provided by BioMed Central/Critical Care. Note: Materials may be edited for content and length.


Journal Reference:

  1. Annette Esper, Marc Moss and Greg S Martin. The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study. Critical Care, (in press)

Cite This Page:

BioMed Central/Critical Care. "Surprising Interactions Of Diabetes Mellitus And Sepsis." ScienceDaily. ScienceDaily, 22 February 2009. <www.sciencedaily.com/releases/2009/02/090212210710.htm>.
BioMed Central/Critical Care. (2009, February 22). Surprising Interactions Of Diabetes Mellitus And Sepsis. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2009/02/090212210710.htm
BioMed Central/Critical Care. "Surprising Interactions Of Diabetes Mellitus And Sepsis." ScienceDaily. www.sciencedaily.com/releases/2009/02/090212210710.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins