Featured Research

from universities, journals, and other organizations

Surprising Interactions Of Diabetes Mellitus And Sepsis

Date:
February 22, 2009
Source:
BioMed Central/Critical Care
Summary:
Diabetic patients are less likely to suffer from acute respiratory failure during severe sepsis. Researchers studied 930 million hospitalizations over a 25-year period to investigate the protective effect, adding to our knowledge of both diabetes and sepsis.

Diabetic patients are less likely to suffer from acute respiratory failure during severe sepsis. Researchers writing in BioMed Central's open access journal Critical Care studied 930 million hospitalisations over a 25-year period to investigate the protective effect, adding to our knowledge of both diabetes and sepsis.

Related Articles


Drs. Annette Esper and Greg Martin from Emory University in Atlanta, Georgia worked with a team of researchers to investigate suspected links between diabetes mellitus (DM) and the likelihood of experiencing different kinds of organ dysfunction during sepsis. He said, "We've found that people with DM and sepsis were more likely to develop acute renal failure than people without DM, while being less likely to develop acute respiratory failure. Findings like these are important, as accurate identification of populations at risk for different acute organ dysfunctions is crucial to the development of novel therapies for these patients."

According to the Surviving Sepsis Campaign, it is estimated that 1,400 people die each day from sepsis. DM is an increasingly common illness, believed to afflict as much as 7% of the population of the US. The authors found that among patients with a respiratory source of sepsis, 16% of those with DM developed acute respiratory failure compared with 23% in people without DM. Among patients with a non-pulmonary source of sepsis, those with DM were still less likely to develop acute respiratory failure when compared with those without DM (6% vs. 10%).

Speculating upon possible reasons for the discrepancy, Martin said, "Possible mechanisms of protection in patients with DM may be impaired neutrophil function or altered neutrophil-endothelial interactions. Alternatively, patients with DM may be hospitalised earlier in the course of their illness than those with no DM because they learn to be aware of specific signs of infection. Finally, pharmacological aspects of DM care may also influence the development of organ dysfunction, because many medications administered to patients with DM, including insulin and thiazolidinediones, are known to have anti-inflammatory effects in addition to lowering blood glucose."


Story Source:

The above story is based on materials provided by BioMed Central/Critical Care. Note: Materials may be edited for content and length.


Journal Reference:

  1. Annette Esper, Marc Moss and Greg S Martin. The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study. Critical Care, (in press)

Cite This Page:

BioMed Central/Critical Care. "Surprising Interactions Of Diabetes Mellitus And Sepsis." ScienceDaily. ScienceDaily, 22 February 2009. <www.sciencedaily.com/releases/2009/02/090212210710.htm>.
BioMed Central/Critical Care. (2009, February 22). Surprising Interactions Of Diabetes Mellitus And Sepsis. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2009/02/090212210710.htm
BioMed Central/Critical Care. "Surprising Interactions Of Diabetes Mellitus And Sepsis." ScienceDaily. www.sciencedaily.com/releases/2009/02/090212210710.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins