Featured Research

from universities, journals, and other organizations

Unrelated And Mismatched Cord Blood Transplantation Can Still Help Children With Deadly Conditions

Date:
February 23, 2009
Source:
Duke University Medical Center
Summary:
An unrelated cord blood transplant, even from a mismatched donor, can be effective in treating children with a host of life-threatening diseases and disorders including cancer, sickle cell anemia, and other genetic diseases, according to researchers. Unrelated cord blood may be easier to obtain than adult bone marrow, allowing for the treatment of more patients.

An unrelated cord blood transplant, even from a mismatched donor, can be effective in treating children with a host of life-threatening diseases and disorders including cancer, sickle cell anemia, and other genetic diseases, according to researchers in the Duke Pediatric Blood and Marrow Transplantation Program. Unrelated cord blood may be easier to obtain than adult bone marrow, allowing for the treatment of more patients.

"We have done a terrific job in this country of increasing the number of volunteer donors listed in the National Marrow Donor Program registry over the past several years," said Vinod Prasad, M.D., a pediatric oncologist at Duke. "But the fact remains that for many patients, finding a matched donor can be difficult. Ethnic and racial minorities have the hardest time finding a fully matched donor."

The researchers will present their findings in an oral presentation at the American Society of Bone Marrow Transplantation in Tampa, Florida, on February 13, 2009.

"Our study found that using cord blood can be effective, without increased complications, and can provide more matches for patients, including ethnic minorities," said Prasad, who was the lead investigator. "Based on the findings of our study, we believe that unrelated cord blood transplant should be considered as an option for many of our young patients in need of a transplant."

Bone marrow transplantation has proven to be an effective treatment for thousands of children in the United States each year diagnosed with diseases such as leukemia and sickle cell disease, and inherited metabolic disorders such as Hurler's syndrome. Patients without a suitable match within their families can turn to the bone marrow registry, which currently lists more than seven million donors. Despite that number, however, many patients, particularly ethnic and racial minorities, are unable to find a completely matched donor.

The vast majority of these patients will find a partially matched donor within the public cord blood banks despite a smaller inventory of donor units, Prasad said.

"In order to match a donor to a recipient, doctors compare HLA typing, a test usually performed on a blood sample. In every individual, HLA typing includes the specific genetic make-up at three locations -- within those locations, you are looking at one set from the mother and one from the father, so it ends up to be six-point comparison," Prasad said. "In this analysis of children whose donor units were matched at four of six points, the transplant was successful in many patients, with low incidence of complications. Results were similar to those seen in patients receiving closer matched transplants. Thus the use of the 4/6 matched donors improved access to transplant for patients, especially those of ethnic and racial minorities."

The researchers studied data taken from 314 patients treated at Duke between 1993 and 2007. The patients ranged in age from six months to 21 years and suffered from both malignant and non-malignant conditions.

"We found that transplantation using 4/6 matched cord blood was effective and also carried a low probability of graft versus host disease, a complication caused by the attacking immune cells from the transplanted blood or marrow that perceive the recipient as 'foreign,' in the same way a healthy body's immune system might fight off a virus," Prasad said. "The incidence of other complications was low as well, and the data suggest that using 4/6 matched cord blood could improve access for all patients."

Other researchers involved in this study include Premjit Gill, Suhag Parikh, Paul Szabolcs, Timothy Driscoll, Kristin Page, Susan Wood, Deborah Semmel, Paul Martin, and Kurtzberg of Duke; and Adam Mendizabal and Shelly Carter, statisticians at the EMMES Corporation.

The study was partially funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Duke University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Duke University Medical Center. "Unrelated And Mismatched Cord Blood Transplantation Can Still Help Children With Deadly Conditions." ScienceDaily. ScienceDaily, 23 February 2009. <www.sciencedaily.com/releases/2009/02/090213114311.htm>.
Duke University Medical Center. (2009, February 23). Unrelated And Mismatched Cord Blood Transplantation Can Still Help Children With Deadly Conditions. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2009/02/090213114311.htm
Duke University Medical Center. "Unrelated And Mismatched Cord Blood Transplantation Can Still Help Children With Deadly Conditions." ScienceDaily. www.sciencedaily.com/releases/2009/02/090213114311.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins