Featured Research

from universities, journals, and other organizations

Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor

Date:
February 19, 2009
Source:
University of Cincinnati
Summary:
Researchers have discovered that estrogen receptors are present in medulloblastoma -- the most common type of pediatric brain tumor -- leading them to believe that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patients' overall outcome.

Scott Belcher, PhD.
Credit: Image courtesy of University of Cincinnati

University of Cincinnati researchers have discovered that estrogen receptors are present in medulloblastoma—the most common type of pediatric brain tumor—leadingthem to believe that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patients’ overall outcome.

Related Articles


This research is being published in the March 2009 edition of Endocrinology.

In estrogen-responsive cancers—such as breast cancer—estrogen receptors act to increase tumor growth and progression. Estrogen receptors are also the most important drug targets for the treatment of breast cancer.

“Current therapies for medulloblastoma involve cranial surgery, chemotherapy and radiation,” says Scott Belcher, PhD, principal investigator of the study. “This discovery suggests that we may be able to use anti-hormone or estrogen drug therapies—like those used to treat breast cancers—to limit progression of these childhood brain tumors and to decrease the adverse side-effects of radiation treatment.”

Medulloblastoma, or MD, is a highly malignant brain tumor, most commonly diagnosed in children.

Patients with MD typically have a five-year survival rate between 50 and 70 percent, and survivors who endure current, more aggressive treatments face an increased risk for chronic illnesses such as diabetes or cardiovascular disease later in life.

Belcher, an associate professor in the department of pharmacology and cell biophysics at UC, and his team examined tumor tissue from 22 patients between the ages of 6 months and 18 years.

They found evidence of estrogen receptors, particularly estrogen receptor beta, in the cancerous cells of every tumor analyzed.

“MD manifests when specific neuron precursors in the brain fail to stop normally differentiating into mature neurons,” Belcher says. “Our previous studies showed that estrogen receptors are regulated during differentiation of these neuronal precursors. MD growth and tumor cell formation can be blocked by inhibiting the activity of these receptors.”

Belcher said these resultsdemonstrate the importance of “bench to bedside” discoveries.

“We started in tumor cells and then moved to animal models of MD and found that we could stop the growth of tumors using anti-estrogen therapies,” he says. “We’ve been able to identify these receptors in humans. We are now hoping that our basic developmental biology findings can take the final step by stopping the growth of these tumors in humans.”

“We believe that development of rational anti-estrogen drug therapies for this highly malignant cancer is a possibility and could improve the lives of many children and adult survivors,” he continues.

This study was funded by the National Institute of Environmental Health Sciences and a Translation Research grant from Cincinnati Children’s Hospital Medical Center.


Story Source:

The above story is based on materials provided by University of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati. "Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor." ScienceDaily. ScienceDaily, 19 February 2009. <www.sciencedaily.com/releases/2009/02/090217112130.htm>.
University of Cincinnati. (2009, February 19). Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2009/02/090217112130.htm
University of Cincinnati. "Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor." ScienceDaily. www.sciencedaily.com/releases/2009/02/090217112130.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins