Featured Research

from universities, journals, and other organizations

Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor

Date:
February 19, 2009
Source:
University of Cincinnati
Summary:
Researchers have discovered that estrogen receptors are present in medulloblastoma -- the most common type of pediatric brain tumor -- leading them to believe that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patients' overall outcome.

Scott Belcher, PhD.
Credit: Image courtesy of University of Cincinnati

University of Cincinnati researchers have discovered that estrogen receptors are present in medulloblastoma—the most common type of pediatric brain tumor—leadingthem to believe that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patients’ overall outcome.

This research is being published in the March 2009 edition of Endocrinology.

In estrogen-responsive cancers—such as breast cancer—estrogen receptors act to increase tumor growth and progression. Estrogen receptors are also the most important drug targets for the treatment of breast cancer.

“Current therapies for medulloblastoma involve cranial surgery, chemotherapy and radiation,” says Scott Belcher, PhD, principal investigator of the study. “This discovery suggests that we may be able to use anti-hormone or estrogen drug therapies—like those used to treat breast cancers—to limit progression of these childhood brain tumors and to decrease the adverse side-effects of radiation treatment.”

Medulloblastoma, or MD, is a highly malignant brain tumor, most commonly diagnosed in children.

Patients with MD typically have a five-year survival rate between 50 and 70 percent, and survivors who endure current, more aggressive treatments face an increased risk for chronic illnesses such as diabetes or cardiovascular disease later in life.

Belcher, an associate professor in the department of pharmacology and cell biophysics at UC, and his team examined tumor tissue from 22 patients between the ages of 6 months and 18 years.

They found evidence of estrogen receptors, particularly estrogen receptor beta, in the cancerous cells of every tumor analyzed.

“MD manifests when specific neuron precursors in the brain fail to stop normally differentiating into mature neurons,” Belcher says. “Our previous studies showed that estrogen receptors are regulated during differentiation of these neuronal precursors. MD growth and tumor cell formation can be blocked by inhibiting the activity of these receptors.”

Belcher said these resultsdemonstrate the importance of “bench to bedside” discoveries.

“We started in tumor cells and then moved to animal models of MD and found that we could stop the growth of tumors using anti-estrogen therapies,” he says. “We’ve been able to identify these receptors in humans. We are now hoping that our basic developmental biology findings can take the final step by stopping the growth of these tumors in humans.”

“We believe that development of rational anti-estrogen drug therapies for this highly malignant cancer is a possibility and could improve the lives of many children and adult survivors,” he continues.

This study was funded by the National Institute of Environmental Health Sciences and a Translation Research grant from Cincinnati Children’s Hospital Medical Center.


Story Source:

The above story is based on materials provided by University of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati. "Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor." ScienceDaily. ScienceDaily, 19 February 2009. <www.sciencedaily.com/releases/2009/02/090217112130.htm>.
University of Cincinnati. (2009, February 19). Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/02/090217112130.htm
University of Cincinnati. "Estrogen Found To Increase Growth Of The Most Common Childhood Brain Tumor." ScienceDaily. www.sciencedaily.com/releases/2009/02/090217112130.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins