Featured Research

from universities, journals, and other organizations

Drug Combination Reduces Kidney Disease Risk In Diabetics

Date:
March 1, 2009
Source:
American Society of Nephrology
Summary:
For patients with type two diabetes, a combination of two blood-pressure-lowering drugs reduces the risk of kidney disease by about 20 percent -- even in patients who don't have high blood pressure, reports a new study.

For patients with type two diabetes, a combination of two blood-pressure-lowering drugs reduces the risk of kidney disease by about 20 percent—even in patients who don't have high blood pressure, reports a study in the April 2009 issue of the Journal of the American Society of Nephrology (JASN).

The analysis was based on the randomized ADVANCE study, which included 11,140 patients with type two diabetes. One group received a combination of two antihypertensive (blood pressure-lowering) drugs: the angiotensin-converting enzyme (ACE) inhibitor perindopril and the diuretic drug indapamide. The other group received inactive placebos.

Although most of the patients had hypertension, 20 percent had normal blood pressure: less than 130/80 millimeters of mercury (mm Hg).

"This research demonstrated that lowering blood pressure with an ACE inhibitor/diuretic combination prevents kidney complications, and even cause some early manifestations of kidney disease in people with diabetes regardless of whether their blood pressure is normal or elevated," comments Vlado Perkovic, MBBS, PhD, of The George Institute for International Health in Sydney, Australia, one of the study authors.

The two groups were followed up to compare their rates of kidney disease events, ranging from a drop in kidney function to kidney failure. An average of four years later, the rate of kidney disease was significantly lower for patients receiving the combination drug therapy—21 percent lower than in the placebo group. In some patients who previously had early signs of diabetes-related kidney disease, kidney function returned to normal during treatment with blood pressure-lowering drugs.

The drug combination reduced kidney disease events even in patients who did not initially have high blood pressure. The lower the blood pressure level, the lower the risk of kidney disease—even at blood pressures below the currently accepted normal level (130/80 mm Hg).

Although more research is needed, these results raise the possibility that patients with type two diabetes should be considered for antihypertensive treatment even if they have normal blood pressure.

The study has some important limitations, including the fact that it was a post-hoc analysis of a previous clinical trial. "Most of the findings related to early manifestations of kidney disease (albuminuria) and the study was not large enough to assess the impact of the intervention directly on the risk of kidney failure," Perkovic adds. "We could not separate out the impact of the blood pressure lowering combination used, or prove whether it had any effects beyond its blood pressure-lowering effects."

ADVANCE was funded by grants from Servier and the National Health and Medical Research Council of Australia.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bastiaan E. de Galan, Vlado Perkovic, Toshiharu Ninomiya, Avinesh Pillai, Anushka Patel, Alan Cass, Bruce Neal, Neil Poulter, Stephen Harrap, Carl-Erik Mogensen, Mark Cooper, Michel Marre, Bryan Williams, Pavel Hamet, Giuseppe Mancia, Mark Woodward, Paul Glasziou, Diederick E. Grobbee, Stephen MacMahon, John Chalmers, and on behalf of the ADVANCE Collaborative Group. Routine Blood Pressure Lowering and Kidney disease in Type 2 Diabetes. J Am Soc Nephrol, 2009; DOI: 10.1681/ASN.2008070667

Cite This Page:

American Society of Nephrology. "Drug Combination Reduces Kidney Disease Risk In Diabetics." ScienceDaily. ScienceDaily, 1 March 2009. <www.sciencedaily.com/releases/2009/02/090218181816.htm>.
American Society of Nephrology. (2009, March 1). Drug Combination Reduces Kidney Disease Risk In Diabetics. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/02/090218181816.htm
American Society of Nephrology. "Drug Combination Reduces Kidney Disease Risk In Diabetics." ScienceDaily. www.sciencedaily.com/releases/2009/02/090218181816.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins