Featured Research

from universities, journals, and other organizations

Tiny Tool To Control Growing Blood Vessels Opens New Potential In Tumor Research

Date:
March 1, 2009
Source:
Uppsala Universitet
Summary:
Researchers have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The findings enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research.

Tiny cultaivation chamber for growing blood vessels.
Credit: Sara Thorslund

Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers’ findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research.

Related Articles


The new invention is a tiny cell cultivation chamber of silicon plastic in which researchers can cultivate blood-vessel-rich tissue and simultaneously create targeted signals that instruct the vessels to go in a certain direction. This is of great interest to the international research world.

Angiogenesis is the process in the body that forms new blood cells, a process that is vital for life but can also be fatal in the worst case. Angiogenesis is desirable, for instance, in connection with wound healing, when new tissue needs to be grown. Undesirable angiogenesis, on the other hand, often occurs in connection with tumor growth. Through the newly generated blood vessels in the vicinity of the tumor, tumor cells receive nourishment and oxygen, which creates the conditions for tumor growth. One way to limit tumor growth may therefore be to counteract the new formation of blood vessels in the tumor, thereby cutting off the supply of nourishment and oxygen to the diseased area.

The scientists Irmeli Berkefors and Johan Kreuger’s research is geared toward understanding the signals that control both normal and pathological angiogenesis. To understand this, it is important to construct experimental model systems in which they can study how concentration gradients of various signal proteins affect the direction in which a vessel grows.

“Our new method enables us to recreate and study gradients that control how blood vessels grow in the body. This is something of a research breakthrough. Now we can systematically evaluate newly identified signals that we hope can ultimately be used to control angiogenesis,” says Johan Kreuger.

The method can also be used to unearth new knowledge regarding how tumor cells and nerve cells grow and move toward gradients of signal proteins.


Story Source:

The above story is based on materials provided by Uppsala Universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Barkefors et al. A fluidic device to study directional angiogenesis in complex tissue and organ culture models. Lab on a Chip, 2009; 9 (4): 529 DOI: 10.1039/b814691h

Cite This Page:

Uppsala Universitet. "Tiny Tool To Control Growing Blood Vessels Opens New Potential In Tumor Research." ScienceDaily. ScienceDaily, 1 March 2009. <www.sciencedaily.com/releases/2009/02/090219081033.htm>.
Uppsala Universitet. (2009, March 1). Tiny Tool To Control Growing Blood Vessels Opens New Potential In Tumor Research. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2009/02/090219081033.htm
Uppsala Universitet. "Tiny Tool To Control Growing Blood Vessels Opens New Potential In Tumor Research." ScienceDaily. www.sciencedaily.com/releases/2009/02/090219081033.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins