Featured Research

from universities, journals, and other organizations

Scientists Study Genes To Improve Warfarin Treatment

Date:
February 20, 2009
Source:
University of Liverpool
Summary:
Scientists have found that information about a patient's genes could help increase the effectiveness of drugs such as warfarin.

Scientists at the University of Liverpool have found that information about a patient’s genes could help increase the effectiveness of drugs such as warfarin.

Related Articles


A team of international researchers, which included scientists from Liverpool and Newcastle University, developed a mathematical formula to understand how genetic information about a patient could help clinicians better predict the appropriate dosage of warfarin – one of the world’s most widely prescribed drugs.

Warfarin is used to prevent blood clots that lead to heart attacks, strokes and in extreme cases, death.  The drug is prescribed to one per cent of patients in the UK, but clinicians have found that the appropriate dose of the drug is difficult to predict because individual patients react differently to it.

Scientists developed a model based on administration of fixed drug dosages per day and standard clinical information about individual patients.  They combined this data with additional information on variations in two genes called, CYP2C9 and VKORC1, which differ slightly among individual patients and are known to influence the effectiveness of warfarin.  Researchers then compared their calculations with actual prescribed dosages, and found that by using the additional genetic information they could better predict the optimal warfarin dose for each patient.

Professor Munir Pirmohamed, from the University’s School of Biomedical Sciences, explains: “Warfarin is amongst the top three drugs responsible for hospital-related adverse drug reactions.  It is also, however, highly beneficial in preventing thrombosis and strokes, and we need to develop methods that improve the benefits and minimize the harms associated with the use of the drug.  The crucial issue is to identify the correct dose for each patient.”

Professor Farhad Kamali, from the University of Newcastle, added: “The way different patients respond to warfarin is notoriously unpredictable, particularly at the start of treatment. Now we know that certain genes can affect the way individual patients respond to warfarin, we can use this information to personalise therapy.”

Liverpool and Newcastle will join research centres across Europe in conducting randomised clinical trials of more than 2,000 new patients to better understand if the more precise, gene-based studies are the best option for patients starting drug treatment.  The trial, called EU-PACT, is due to start in October this year and patients will be recruited through doctors in the Liverpool and Newcastle region.

The warfarin studies are supported by the Department of Health. The EU-PACT trial is being supported by the EU FP7 Framework programme.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Cite This Page:

University of Liverpool. "Scientists Study Genes To Improve Warfarin Treatment." ScienceDaily. ScienceDaily, 20 February 2009. <www.sciencedaily.com/releases/2009/02/090220075141.htm>.
University of Liverpool. (2009, February 20). Scientists Study Genes To Improve Warfarin Treatment. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2009/02/090220075141.htm
University of Liverpool. "Scientists Study Genes To Improve Warfarin Treatment." ScienceDaily. www.sciencedaily.com/releases/2009/02/090220075141.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins