Featured Research

from universities, journals, and other organizations

Brain’s Reserve Cells Can Be Activated After Stroke

Date:
March 2, 2009
Source:
Karolinska Institutet
Summary:
Scientists have found a way of activating the neuronal reserves in the brains of mice by switching off the signal that inhibits the formation of new nerve cells.

Scientists at the Swedish medical university Karolinska Institutet have found a way of activating the neuronal reserves in the brains of mice by switching off the signal that inhibits the formation of new nerve cells.

"So far, this is just basic research of no immediate practical significance, but the results are very exciting nonetheless," says Professor Jonas Frisιn at the Department of Cell and Molecular Biology, who led the study.

New nerve cells are formed from stem cells in specific areas of the human brain. This process increases after a stroke, something that might explain the recovery that is often observed in patients, particularly in the first year following the onset of illness. In the present study, the scientists have demonstrated how a type of cell that does not give rise to new cells in the healthy brain is activated after a stroke in laboratory animals.

In addition to the stem cells that are normally active, there is therefore also a kind of reserve stock of cells the can be activated when demand increases. The team have identified the molecular mechanisms that control the activation of these cells, and shown that it is possible to increase the formation of new nerve cells in healthy mice by switching off the so-called Notch signalling pathway, which inhibits the creation of new nerve cells.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carlιn et al. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nature Neuroscience, Feb 22, 2009; DOI: 10.1038/nn.2268

Cite This Page:

Karolinska Institutet. "Brain’s Reserve Cells Can Be Activated After Stroke." ScienceDaily. ScienceDaily, 2 March 2009. <www.sciencedaily.com/releases/2009/02/090223083346.htm>.
Karolinska Institutet. (2009, March 2). Brain’s Reserve Cells Can Be Activated After Stroke. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/02/090223083346.htm
Karolinska Institutet. "Brain’s Reserve Cells Can Be Activated After Stroke." ScienceDaily. www.sciencedaily.com/releases/2009/02/090223083346.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) — In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) — The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins